van Hulzen Z J, van der Staay F J
Department of Psychology, University of Nijmegen, The Netherlands.
Physiol Behav. 1991 Jul;50(1):121-7. doi: 10.1016/0031-9384(91)90507-k.
It was investigated in rats whether hippocampal long-term potentiation (LTP) influences working and/or reference memory processing in the radial maze. After preliminary training to an intermediate level of performance, experimental subjects received a series of high-frequency trains of electrical pulses applied to the right perforant path. Two control groups were adopted in order to control for possible effects of stimulation plus operation, and operation alone, respectively. Twenty-four hours after the experimental treatment, animals were administered one trial of radial maze training. This sequence of hippocampal stimulation and radial maze training was replicated 15 times. After a retention interval of 2 months, one radial maze trial was presented on each of 3 consecutive days. The analysis of field potential data showed that periodic LTP stimulation produced a state of hippocampal LTP confined to the initial portion of the acquisition phase. Evaluation of radial maze data revealed a marginal improvement of working memory performance in the experimental group during the rising phase of hippocampal LTP.
在大鼠中研究了海马长时程增强（LTP）是否影响放射状迷宫中的工作记忆和/或参考记忆处理。在初步训练至中等表现水平后，实验对象接受一系列施加于右侧穿通通路的高频电脉冲串。采用两个对照组，分别控制刺激加手术以及单独手术可能产生的影响。实验处理24小时后，对动物进行一次放射状迷宫训练。海马刺激和放射状迷宫训练的这个序列重复了15次。在2个月的保留期后，连续3天每天进行一次放射状迷宫试验。场电位数据分析表明，周期性LTP刺激产生了局限于习得阶段初始部分的海马LTP状态。对放射状迷宫数据的评估显示，在海马LTP上升阶段，实验组的工作记忆表现有轻微改善。
