Robinson G B, McNeill H A, Reed G D
Department of Psychology, University of New Brunswick, Fredericton, Canada.
Behav Neurosci. 1993 Dec;107(6):988-95.
The present experiment compared the long-lasting with the short-lasting effects of kindling the perforant path input to the hippocampal formation on the acquisition of two radial maze tasks. Animals in the long-term group were fully kindled (i.e., Stage 5 motor seizures were evoked) prior to a stimulation-free training period. Animals in the short-term group were kindled 30-45 min prior to each learning trial. A third group of animals served as controls and were never kindled. On both 8-arm and 4/8-arm radical maze tasks, learning impairments were apparent only in the short-term group. Thus, the impaired learning is more likely related to the short-term aftereffects of an afterdischarge than to any long-term alterations in the neuronal status of the brain caused by kindling.
本实验比较了点燃海马结构的穿通通路输入对两个放射状迷宫任务习得的长期和短期影响。长期组的动物在无刺激训练期之前被完全点燃（即诱发5期运动性癫痫发作）。短期组的动物在每次学习试验前30 - 45分钟被点燃。第三组动物作为对照组，从未被点燃。在8臂和4/8臂放射状迷宫任务中，学习障碍仅在短期组中明显。因此，学习受损更可能与放电后效的短期影响有关，而不是与点燃引起的大脑神经元状态的任何长期改变有关。
