Knowlton B J, Shapiro M L, Olton D S
Johns Hopkins University.
Behav Neurosci. 1989 Oct;103(5):1144-7. doi: 10.1037//0735-7044.103.5.1144.
The effect of hippocampal seizures in rats was assessed in two spatial memory tasks: The reference memory task was a simultaneous two-choice discrimination in a T-maze. The working memory task was a delayed conditional discrimination in a radial arm maze. In each task the hippocampus of each rat was stimulated to seizure after the presentation of the information to be remembered. In the reference memory task, hippocampal seizures did not impair acquisition, whether the stimulation was given immediately after or 4 hr after the presentation of the stimuli to be remembered. In the working memory task, hippocampal seizures did impair performance in a group of the same rats. These results support the distinction between a trial-dependent working memory system that requires hippocampal function and a trial-independent memory system that does not depend on hippocampal function.
参考记忆任务是在T型迷宫中进行的同时性二选一辨别任务。工作记忆任务是在放射状臂迷宫中进行的延迟条件辨别任务。在每项任务中，每只大鼠的海马体在呈现需记忆的信息后受到刺激引发癫痫发作。在参考记忆任务中，无论在呈现需记忆的刺激后立即给予刺激还是在4小时后给予刺激，海马体癫痫发作均不损害记忆获得。在工作记忆任务中，海马体癫痫发作确实损害了同一组大鼠中的部分大鼠的表现。这些结果支持了依赖试验的工作记忆系统（需要海马体功能）和不依赖试验的记忆系统（不依赖海马体功能）之间的区别。
