具有类酶催化活性的聚乙烯亚胺合成衍生物（合成酶）。
Synthetic derivatives of polyethyleneimine with enzyme-like catalytic activity (synzymes).
作者信息
Klotz I M, Royer G P, Scarpa I S
机构信息
Biochemistry Division, Department of Chemistry, Northwestern University, Evanston, Illinois 60201.
出版信息
Proc Natl Acad Sci U S A. 1971 Feb;68(2):263-4. doi: 10.1073/pnas.68.2.263.
Abstract
A synthetic polymer has been prepared which contains dodecyl groups (to bind small substrate molecules) and methyleneimidazole side chains (as nucleophilic catalytic sites) linked to a polyethyleneimine framework. This macromolecule, with a high local concentration of binding and catalytic groups, catalyzes the hydrolysis of uncharged nitrophenyl esters in water at pH 7 with rates markedly greater than previously observed with any other synthetic substances under similar conditions.
摘要
一种合成聚合物已被制备出来，它含有十二烷基（用于结合小的底物分子）和连接到聚乙烯亚胺骨架上的亚甲基咪唑侧链（作为亲核催化位点）。这种大分子具有高局部浓度的结合和催化基团，在pH 7的水中催化不带电荷的硝基苯酯的水解，其速率明显高于在类似条件下用任何其他合成物质所观察到的速率。
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