Gardner B P, Margolis T P, Mondino B J
Jules Stein Eye Institute, University of California, Los Angeles Medical Center.
Am J Ophthalmol. 1991 Nov 15;112(5):567-71. doi: 10.1016/s0002-9394(14)76860-6.
Infection with Epstein-Barr virus has been reported to have numerous systemic and ocular manifestations. In this study, a 38-year-old man with acute infectious mononucleosis was examined for a painless left red eye of three days' duration. The patient had a two-week history of fatigue, low-grade fever, sore throat, and lymphadenopathy. Serologic evaluation was indicative of an acute primary infection with Epstein-Barr virus. A large, salmon-colored, supranasal bulbar conjunctival mass was observed in the left eye. No associated conjunctivitis was present. Biopsy of the conjunctival lesion disclosed a dense leukocytic infiltrate, which consisted primarily of mature lymphocytes and plasma cells. Immunocytochemical evaluation of the tissue with monoclonal antisera disclosed Epstein-Barr latent membrane protein and nuclear protein 2 in a small fraction of the cells constituting the infiltrate. The conjunctival infiltrate resolved completely within one month, paralleling the regression of the patient's lymphadenopathy.
据报道，感染爱泼斯坦-巴尔病毒会出现多种全身和眼部表现。在本研究中，一名38岁患有急性传染性单核细胞增多症的男性因左眼无痛性发红且持续三天而接受检查。患者有两周的疲劳、低热、咽痛和淋巴结病病史。血清学评估表明为急性原发性爱泼斯坦-巴尔病毒感染。左眼可见一个大的、鲑鱼色的鼻上方球结膜肿物。未伴有结膜炎。结膜病变活检显示有密集的白细胞浸润，主要由成熟淋巴细胞和浆细胞组成。用单克隆抗血清对组织进行免疫细胞化学评估发现，在构成浸润的一小部分细胞中存在爱泼斯坦-巴尔潜伏膜蛋白和核蛋白2。结膜浸润在一个月内完全消退，与患者淋巴结病的消退情况平行。
