Feinberg A S, Spraul C W, Holden J T, Grossniklaus H E
Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA.
Ophthalmology. 2000 Jan;107(1):159-63. doi: 10.1016/s0161-6420(99)00014-7.
To describe the clinicopathologic features of two patients with Epstein-Barr virus (EBV) associated conjunctival lymphocytic infiltrates.
Two case reports.
The clinical histories and pathologic findings of two patients with salmon-colored conjunctival infiltrates are described.
Clinical observation and pathologic examination of conjunctival biopsy specimens with accompanying immunohistochemical staining, flow cytometric immunophenotyping, and polymerase chain reaction analysis when appropriate.
One patient had ipsilateral preauricular lymphadenopathy, elevated serum EBV titers, and a unilateral reactive lymphocytic infiltrate resulting in a conjunctival mass. The other patient had bilateral conjunctival lymphocytic infiltrates causing conjunctival masses. There was an expanded clonal population of B lymphocytes in the conjunctival mass in the second patient. Both patients had EBV antigen in their conjunctival lymphocytic infiltrates.
Conjunctival lymphocytic lesions associated with EBV represent a spectrum of reactive infiltrates to monoclonal populations.
描述两例与爱泼斯坦-巴尔病毒（EBV）相关的结膜淋巴细胞浸润患者的临床病理特征。
两例病例报告。
描述了两例患有鲑鱼色结膜浸润患者的临床病史和病理检查结果。
对结膜活检标本进行临床观察和病理检查，并在适当情况下进行免疫组化染色、流式细胞免疫表型分析和聚合酶链反应分析。
一例患者有同侧耳前淋巴结肿大、血清EBV滴度升高，单侧反应性淋巴细胞浸润导致结膜肿物。另一例患者有双侧结膜淋巴细胞浸润导致结膜肿物。第二例患者结膜肿物中有B淋巴细胞的克隆性扩增群体。两例患者的结膜淋巴细胞浸润中均有EBV抗原。
与EBV相关的结膜淋巴细胞病变代表了从反应性浸润到单克隆群体的一系列病变。
