Eibling D E, Johnson J T, McCoy J P, Barnes E L, Syms C A, Wagner R L, Campbell J
Department of Otolaryngology, University of Pittsburgh School of Medicine, Pennsylvania.
Am J Surg. 1991 Oct;162(4):367-72. doi: 10.1016/0002-9610(91)90150-c.
Adenoid cystic carcinoma is an unusual but capricious tumor of salivary gland origin. Characteristically, these tumors follow a relentless clinical course, although some patients experience prolonged disease-free survival. Tumor size, site, and grade have been shown to correlate with tumor behavior. Recent investigation by others has suggested that DNA ploidy as determined by flow cytometry may provide an additional biologic marker of tumor behavior. This study was undertaken to investigate the relationship of DNA ploidy to tumor grade, biologic behavior, and patient outcome. A retrospective comparison of flow cytometric evaluations of paraffin-embedded formalin-fixed tumor specimens with patient outcome and histopathologic grade was undertaken. Follow-up of 4 to 7 years in 26 patients confirmed that the presence of a solid histologic component in the tumor correlated with the presence of recurrent or persistent disease (p = 0.04). Twenty-two of 28 tumors (78%) were found to be aneuploid on at least one section. Comparison of DNA ploidy with either patient outcome or the presence of a solid component did not achieve statistical significance, although a trend was suggested. This study confirms previous studies demonstrating the validity of histopathologic evaluation of tumor grade in the prediction of the biologic behavior of adenoid cystic carcinoma. However, our findings suggest that DNA ploidy has only limited value as an additional marker of tumor behavior in this patient population.
腺样囊性癌是一种起源于唾液腺的罕见但变化无常的肿瘤。其特点是，尽管有些患者经历了较长时间的无病生存期，但这些肿瘤通常会呈现出持续进展的临床过程。肿瘤大小、部位和分级已被证明与肿瘤行为相关。其他人最近的研究表明，通过流式细胞术测定的DNA倍性可能为肿瘤行为提供另一种生物学标志物。本研究旨在探讨DNA倍性与肿瘤分级、生物学行为及患者预后之间的关系。对石蜡包埋、福尔马林固定的肿瘤标本进行流式细胞术评估，并与患者预后和组织病理学分级进行回顾性比较。对26例患者进行了4至7年的随访，结果证实肿瘤中实性组织成分的存在与复发或持续性疾病的存在相关（p = 0.04）。28个肿瘤中有22个（78%）在至少一个切片上被发现为非整倍体。尽管有一定趋势，但DNA倍性与患者预后或实性成分存在情况的比较未达到统计学意义。本研究证实了先前的研究，即肿瘤分级的组织病理学评估在预测腺样囊性癌生物学行为方面的有效性。然而，我们的研究结果表明，在该患者群体中，DNA倍性作为肿瘤行为的附加标志物价值有限。
