Istituto di Mutagenesi e Differenziamento, Consiglio Nazionale delle Richerche, Via Svezia, 10, I-56100 Pisa, Italy.
Proc Natl Acad Sci U S A. 1985 May;82(9):2799-803. doi: 10.1073/pnas.82.9.2799.
Carrot cells are capable of inactivating alpha-amanitin only in embryogenic conditions (regenerating cells and embryoids). Instead, the mutant line a3 is capable of inactivating the drug also in nonembryogenic conditions (vegetative growth). The mutation is dominant in somatic hybrids and is pleiotropic, allowing expression during vegetative growth of other embryonal functions. The inactivation of alpha-amanitin is due to the oxidative activity of tyrosinase.
胡萝卜细胞仅在胚胎发生条件下（再生细胞和胚状体）才能使α-鹅膏蕈碱失活。相反，突变株 a3 也能够在非胚胎发生条件下（营养生长）使药物失活。该突变在体细胞杂种中是显性的，并且是多效的，允许在营养生长期间表达其他胚胎功能。α-鹅膏蕈碱的失活是由于酪氨酸酶的氧化活性。
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