Joseph Henry Laboratories of Physics, Princeton University, Princeton, NJ 08544.
Proc Natl Acad Sci U S A. 1985 Jun;82(11):3670-2. doi: 10.1073/pnas.82.11.3670.
Many proteins have been observed to exist in a large number of conformations that are believed to play an important role in their dynamics. A model of protein conformational substates that incorporates the ideas of frustration and disorder in analogy to glasses and spin glasses is proposed. Applications to x-ray diffraction, Mössbauer studies, and recombination experiments are discussed.
许多蛋白质被观察到存在于大量构象中,这些构象被认为在其动力学中起着重要作用。提出了一种蛋白质构象亚稳态模型,该模型借鉴了玻璃和自旋玻璃的无序和挫折思想。讨论了其在 X 射线衍射、穆斯堡尔研究和重组实验中的应用。