生物分子的能量景观与动力学扩展摘要
Energy landscape and dynamics of biomolecules extended abstract.
作者信息
Frauenfelder Hans
机构信息
Theory Division T10, Los Alamos National Laboratory, Los Alamos, NM 87545.
出版信息
J Biol Phys. 2005 Dec;31(3-4):413-6. doi: 10.1007/s10867-005-0696-4.
Abstract
Proteins are not isolated homogeneous systems. Each protein can exist in a very large number of conformations (conformational substates) that are characterized by an energy landscape. The main conformational motions, similar to the α and β fluctuations in glasses, are linked to fluctuations in the bulk solvent and the hydration shell.
摘要
蛋白质并非孤立的均匀体系。每种蛋白质都能以大量构象（构象亚态）存在，这些构象由能量景观所表征。与玻璃中的α和β波动相似，主要的构象运动与本体溶剂和水化层中的波动相关。
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本文引用的文献
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Bulk-solvent and hydration-shell fluctuations, similar to alpha- and beta-fluctuations in glasses, control protein motions and functions.大量溶剂和水化层波动，类似于玻璃中的α和β波动，控制着蛋白质的运动和功能。
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