Savannah River Ecology Laboratory, Drawer E. University of Georgia, Aiken, SC 29801.
Proc Natl Acad Sci U S A. 1988 Dec;85(24):9621-4. doi: 10.1073/pnas.85.24.9621.
Genetic diversity in natural populations of the bacterium Pseudomonas cepacia was surveyed in 10 enzymes from 70 clones isolated along a landscape gradient. Estimates of genetic diversity, ranging from 0.54 to 0.70, were higher than any previously reported values of which we are aware and were positively correlated with habitat variability. Patterns of bacterial genetic diversity were correlated with habitat variability. Findings indicate that the source of strains used in genetic engineering will greatly affect the outcome of planned releases in variable environments. Selection of generalist strains may confer a large advantage to engineered populations, while selection of laboratory strains may result in quick elimination of the engineered strains.
对沿景观梯度分离的 70 个克隆中的 10 种酶进行了假单胞菌属细菌自然种群的遗传多样性调查。遗传多样性的估计值范围从 0.54 到 0.70,高于我们所知的任何以前报告的值,并且与生境可变性呈正相关。细菌遗传多样性的模式与生境可变性相关。研究结果表明,遗传工程中使用的菌株来源将极大地影响在多变环境中计划释放的结果。选择广域种菌株可能会给工程种群带来巨大优势,而选择实验室菌株可能会导致工程菌株迅速消失。