Fraser R, Connell J M, Budd P S, Corrie J E, Kenyon C J
MRC Blood Pressure Unit, Western Infirmary, Glasgow, Scotland.
J Steroid Biochem Mol Biol. 1991 Nov;39(5B):839-50. doi: 10.1016/0960-0760(91)90034-3.
18-Hydroxycortisol has been suggested as a marker compound for a transitional zone between the adrenocortical zonae glomerulosa and fasciculata. The control of secretion of 18-hydroxycortisol has been compared with those of cortisol and aldosterone in normal subjects and patients with primary hyperaldosteronism. Comparisons were also made in isolated bovine zona glomerulosa and zona fasciculata cell preparations. Although there was considerable cross-contamination between fractions, 18-hydroxycortisol secretion occurred with equal facility in both fractions but depended on the availability of cortisol as substrate. Changes in secretion during stimulation following those of cortisol. It is concluded that, in vivo, 18-hydroxycortisol derives mainly from the zona fasciculata. The relevance of these findings to primary hyperaldosteronism and to the nature of the transition is discussed.
18-羟皮质醇被认为是肾上腺皮质球状带和束状带之间过渡区的一种标记化合物。在正常受试者和原发性醛固酮增多症患者中，对18-羟皮质醇分泌的调控与皮质醇和醛固酮的调控进行了比较。还在分离的牛球状带和束状带细胞制剂中进行了比较。尽管各部分之间存在相当程度的交叉污染，但18-羟皮质醇在两个部分中分泌的难易程度相同，但取决于皮质醇作为底物的可用性。刺激后其分泌变化与皮质醇的变化一致。得出的结论是，在体内，18-羟皮质醇主要来源于束状带。讨论了这些发现与原发性醛固酮增多症以及过渡性质的相关性。
