Cao Yihai
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
J Clin Invest. 2007 Sep;117(9):2362-8. doi: 10.1172/JCI32239.
Substantial evidence shows that neoplastic and nonneoplastic tissue growth is dependent on angiogenesis. Neovascularization and adipogenesis are temporally and spatially coupled processes during prenatal life and they continue to reciprocally interact via paracrine signaling systems throughout adult life. Activated adipocytes produce multiple angiogenic factors including leptin, angiopoietins, HGF, GM-CSF, VEGF, FGF-2, and TGF-beta, which either alone or collectively stimulate neovascularization during fat mass expansion. Thus antiangiogenic agents provide a novel therapeutic option for prevention and treatment of human obesity and its related disorders.
大量证据表明，肿瘤性和非肿瘤性组织生长依赖于血管生成。在产前生活中，新血管形成和脂肪生成是在时间和空间上相互关联的过程，并且在整个成年期它们通过旁分泌信号系统持续相互作用。活化的脂肪细胞产生多种血管生成因子，包括瘦素、血管生成素、肝细胞生长因子、粒细胞-巨噬细胞集落刺激因子、血管内皮生长因子、成纤维细胞生长因子-2和转化生长因子-β，这些因子单独或共同在脂肪量增加期间刺激新血管形成。因此，抗血管生成药物为预防和治疗人类肥胖及其相关疾病提供了一种新的治疗选择。
