氨基糖苷类与RNA及核酸酶的相互作用。
Aminoglycoside interactions with RNAs and nucleases.
作者信息
Kirsebom L A, Virtanen A, Mikkelsen N E
机构信息
Department of Cell and Molecular Biology, Biomedical Center, Uppsala University, Box 596, Uppsala, Sweden.
出版信息
Handb Exp Pharmacol. 2006;173(173):73-96. doi: 10.1007/3-540-27262-3_4.
One of the major challenges in medicine today is the development of new antibiotics as well as effective antiviral agents. The well-known aminoglycosides interact and interfere with the function of several noncoding RNAs, among which ribosomal RNAs (rRNAs) are the best studied. Aminoglycosides are also known to interact with proteins such as ribonucleases. Here we review our current understanding of the interaction between aminoglycosides and RNA. Moreover, we discuss briefly mechanisms behind the inactivation of aminoglycosides, a major concern due to the increasing appearance of multiresistant bacterial strains. Taken together, the general knowledge about aminoglycoside and RNA interaction is of utmost importance in the process of identifying/developing the next generation or new classes of antibiotics. In this perspective, previously unrecognized as well as known noncoding RNAs, apart from rRNA, are promising targets to explore.
当今医学面临的主要挑战之一是开发新型抗生素以及有效的抗病毒药物。著名的氨基糖苷类药物会与几种非编码RNA相互作用并干扰其功能，其中核糖体RNA（rRNA）是研究得最为透彻的。氨基糖苷类药物还已知会与诸如核糖核酸酶等蛋白质相互作用。在此，我们综述了目前对氨基糖苷类药物与RNA相互作用的理解。此外，我们简要讨论了氨基糖苷类药物失活背后的机制，由于多重耐药细菌菌株的日益出现，这是一个主要问题。综上所述，关于氨基糖苷类药物与RNA相互作用的一般知识在鉴定/开发下一代或新型抗生素的过程中至关重要。从这个角度来看，除了rRNA之外，以前未被认识以及已知的非编码RNA都是值得探索的有前景的靶点。
Zotero 插件