小RNA与免疫

Small RNAs and immunity.

作者信息

McManus Michael T

机构信息

UCSF Diabetes Center, Department of Microbiology and Immunology, University of California, San Francisco, CA 94122, USA.

出版信息

Immunity. 2004 Dec;21(6):747-56. doi: 10.1016/j.immuni.2004.11.007.

DOI:10.1016/j.immuni.2004.11.007

PMID:15589164

Abstract

Small RNAs of 21-23 nucleotides are powerful regulators of gene expression and play essential roles in biological processes that include development, maintenance of genome stability, and viral adaptive defense mechanisms. Such small RNAs are simple in design yet rich in biology and have captivated the attention of biologists in many fields. This review discusses the potential roles of small RNAs in immune biology and speculates on their potential participation in lymphogenesis and antiviral mechanisms.

摘要

21至23个核苷酸的小RNA是基因表达的强大调节因子，在包括发育、基因组稳定性维持和病毒适应性防御机制等生物过程中发挥着重要作用。这类小RNA设计简单但生物学特性丰富，吸引了许多领域生物学家的关注。本文综述讨论了小RNA在免疫生物学中的潜在作用，并推测了它们在淋巴细胞生成和抗病毒机制中的潜在参与情况。