Loganathan Rajprasad, Bilgen Mehmet, Al-Hafez Baraa, Alenezy Mohammed D, Smirnova Irina V
Department of Physical Therapy and Rehabilitation Science, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Cardiovasc Diabetol. 2006 Apr 4;5:7. doi: 10.1186/1475-2840-5-7.
Diabetes is a major risk factor for cardiovascular disease. In particular, type 1 diabetes compromises the cardiac function of individuals at a relatively early age due to the protracted course of abnormal glucose homeostasis. The functional abnormalities of diabetic myocardium have been attributed to the pathological changes of diabetic cardiomyopathy.
In this study, we used high field magnetic resonance imaging (MRI) to evaluate the left ventricular functional characteristics of streptozotocin treated diabetic Sprague-Dawley rats (8 weeks disease duration) in comparison with age/sex matched controls.
Our analyses of EKG gated cardiac MRI scans of the left ventricle showed a 28% decrease in the end-diastolic volume and 10% increase in the end-systolic volume of diabetic hearts compared to controls. Mean stroke volume and ejection fraction in diabetic rats were decreased (48% and 28%, respectively) compared to controls. Further, dV/dt changes were suggestive of phase sensitive differences in left ventricular kinetics across the cardiac cycle between diabetic and control rats.
Thus, the MRI analyses of diabetic left ventricle suggest impairment of diastolic and systolic hemodynamics in this rat model of diabetic cardiomyopathy. Our studies also show that in vivo MRI could be used in the evaluation of cardiac dysfunction in this rat model of type 1 diabetes.
糖尿病是心血管疾病的主要危险因素。特别是，1型糖尿病由于长期的血糖稳态异常，在相对较早的年龄就会损害个体的心脏功能。糖尿病心肌的功能异常归因于糖尿病性心肌病的病理变化。
在本研究中，我们使用高场磁共振成像（MRI）来评估链脲佐菌素处理的糖尿病Sprague-Dawley大鼠（病程8周）的左心室功能特征，并与年龄/性别匹配的对照组进行比较。
我们对左心室的心电图门控心脏MRI扫描分析显示，与对照组相比，糖尿病心脏的舒张末期容积减少28%，收缩末期容积增加10%。与对照组相比，糖尿病大鼠的平均每搏输出量和射血分数降低（分别为48%和28%）。此外，dV/dt变化提示糖尿病大鼠和对照大鼠在整个心动周期中左心室动力学存在相位敏感差异。
因此，对糖尿病左心室的MRI分析表明，在这种糖尿病性心肌病大鼠模型中存在舒张期和收缩期血流动力学损害。我们的研究还表明，体内MRI可用于评估这种1型糖尿病大鼠模型中的心脏功能障碍。
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