Shi Chunyan, Zhang Hongkai, Zhang Nan, Liu Dongting, Fan Zhanming, Sun Zhonghua, Liu Jiayi, Xu Lei
Department of Radiology, Beijing Anzhen Hospital, Beijing Institute of Heart, Lung & Vascular Diseases, Capital Medical University, Beijing 100029, China.
Discipline of Medical Radiation Science, Curtin Medical School, Perth 6102, Australia.
J Clin Med. 2022 Jul 22;11(15):4262. doi: 10.3390/jcm11154262.
Type 2 diabetes mellitus (T2DM) is associated with a high prevalence of diastolic dysfunction and congestive heart failure. A potential contributing factor is the accelerated accumulation of diffuse myocardial fibrosis and stiffness. Novel cardiac magnetic resonance (CMR) imaging techniques can identify both myocardial fibrosis and contractility quantitatively. This study aimed to investigate the dynamic characteristics of the myocardial strain and altered extracellular volume (ECV) fraction as determined by 7.0 T CMR in T2DM mice. C57Bl/6J mice were randomly divided into T2DM (fed a high-fat diet) and control (fed a normal diet) groups. They were scanned on 7.0 T MRI every 4 weeks until the end of week 24. The CMR protocol included multi-slice cine imaging to assess left ventricle strain and strain rate, and pre- and post-contrast T1 mapping images to quantify ECV. The ECV in the T2DM mice was significantly higher (p < 0.05) than that in the control group since week 12 with significantly impaired myocardial strain (p < 0.05). A significant linear correlation was established between myocardial strain and ECV (p < 0.001) and left ventricular-ejection fraction and ECV (p = 0.003). The results suggested that CMR feature tracking-derived myocardial strain analysis can assess functional abnormalities that may be associated with ECM alterations in diabetic cardiomyopathy, contributing to the study of diabetic therapy effects.
2型糖尿病（T2DM）与舒张功能障碍和充血性心力衰竭的高患病率相关。一个潜在的促成因素是弥漫性心肌纤维化和僵硬的加速积累。新型心脏磁共振（CMR）成像技术可以定量识别心肌纤维化和收缩性。本研究旨在探讨7.0 T CMR测定的T2DM小鼠心肌应变和细胞外容积（ECV）分数改变的动态特征。C57Bl/6J小鼠随机分为T2DM组（高脂饮食喂养）和对照组（正常饮食喂养）。每4周对它们进行一次7.0 T MRI扫描，直至第24周结束。CMR方案包括多层电影成像以评估左心室应变和应变率，以及对比剂前和对比剂后T1映射图像以量化ECV。自第12周起，T2DM小鼠的ECV显著高于对照组（p < 0.05），心肌应变显著受损（p < 0.05）。心肌应变与ECV之间（p < 0.001）以及左心室射血分数与ECV之间（p = 0.003）建立了显著的线性相关性。结果表明，CMR特征追踪衍生的心肌应变分析可以评估可能与糖尿病性心肌病中细胞外基质改变相关的功能异常，有助于糖尿病治疗效果的研究。
