Tziakas Dimitrios N, Chalikias Georgios K, Kaski Juan Carlos
University Cardiology Department, Democritus University of Thrace, Alexandroupolis, Greece.
Coron Artery Dis. 2005 Nov;16 Suppl 1:S3-S10. doi: 10.1097/00019501-200511001-00002.
Diabetes mellitus is a worldwide epidemic. Cardiovascular disease remains the major cause of morbidity and mortality in people with diabetes. Studies have suggested that increased risk of cardiovascular disease is not restricted to type II or type I diabetes mellitus, but extends to prediabetic stages such as impaired fasting glucose, impaired glucose tolerance, metabolic syndrome, and obesity. Insulin resistance, impaired fasting glucose, impaired glucose tolerance, and diabetes mellitus form a continuous sequence of risk for cardiovascular disease. Therefore, cardiovascular disease mortality and morbidity within the diabetes epidemic grow into vast proportions. Evidence also exists that diabetic patients have a high prevalence of heart failure or impaired diastolic and systolic cardiac function subsequent to the combination of coronary artery disease, hypertension, and diabetic cardiomyopathy. In view of the proportions of this new epidemic, prevention of diabetes and its prediabetic states is likely to be the most effective strategy to prevent serious cardiovascular events.
糖尿病是一种全球性的流行病。心血管疾病仍然是糖尿病患者发病和死亡的主要原因。研究表明，心血管疾病风险的增加不仅限于2型或1型糖尿病，还延伸到糖尿病前期阶段，如空腹血糖受损、糖耐量受损、代谢综合征和肥胖。胰岛素抵抗、空腹血糖受损、糖耐量受损和糖尿病形成了心血管疾病风险的连续序列。因此，糖尿病流行中的心血管疾病死亡率和发病率大幅上升。也有证据表明，由于冠状动脉疾病、高血压和糖尿病性心肌病的共同作用，糖尿病患者心力衰竭或舒张和收缩心脏功能受损的患病率很高。鉴于这一新流行病的规模，预防糖尿病及其糖尿病前期状态可能是预防严重心血管事件的最有效策略。
