RCAS1在胶质瘤中的临床病理意义：肿瘤免疫逃逸的潜在机制

Clinico-pathological significance of RCAS1 expression in gliomas: a potential mechanism of tumor immune escape.

作者信息

Nakabayashi Hiromichi, Nakashima Manabu, Hara Mitsuhiro, Toyonaga Shinichi, Yamada Shoko M, Park Kae Chang, Shimizu Keiji

机构信息

Department of Neurosurgery, Kochi Medical School, Kochi University, Kohasu, Kochi, Japan.

出版信息

Cancer Lett. 2007 Feb 8;246(1-2):182-9. doi: 10.1016/j.canlet.2006.02.021. Epub 2006 Apr 3.

DOI:10.1016/j.canlet.2006.02.021

PMID:16595162

Abstract

RCAS1, one of the tumor cell surface antigens, is strongly expressed in aggressive tumors. RCAS1 suppresses the in vitro growth of immune effector cells. We investigated the expression of RCAS1 in 57 gliomas using immunohistochemistry. Furthermore, we examined the association of the RCAS1 expression with the infiltration of tumor infiltrating lymphocyte (TIL). RCAS1 overexpression was significantly correlated with high histological grade and poor prognosis. Reduced infiltration and increased apoptosis of TILs was observed in RCAS1-positive regions. Apoptotsis of TILs appeared to be induced by RCAS1. RCAS1 expression in gliomas may play roles in tumor progression and tumor immune escape.

摘要

RCAS1是肿瘤细胞表面抗原之一，在侵袭性肿瘤中强烈表达。RCAS1可抑制免疫效应细胞的体外生长。我们采用免疫组织化学方法研究了57例胶质瘤中RCAS1的表达情况。此外，我们还检测了RCAS1表达与肿瘤浸润淋巴细胞（TIL）浸润之间的关系。RCAS1的过表达与高组织学分级和不良预后显著相关。在RCAS1阳性区域观察到TIL浸润减少和凋亡增加。TIL的凋亡似乎是由RCAS1诱导的。胶质瘤中RCAS1的表达可能在肿瘤进展和肿瘤免疫逃逸中发挥作用。