Frich L, Mala T, Gladhaug I P
The Interventional Centre, Rikshospitalet University Hospital, Oslo, Norway.
Eur J Surg Oncol. 2006 Jun;32(5):527-32. doi: 10.1016/j.ejso.2006.02.021. Epub 2006 Apr 3.
To assess the influence of the Pringle manoeuvre on volume and geometry of coagulations close to the portal vein using an impedance-controlled radiofrequency ablation system with perfusion electrodes.
Twelve pigs were randomly assigned to a control group (n = 6) and a group where the Pringle manoeuvre was applied during ablation (n = 6). One coagulation was made in each animal close to the portal vein. All animals were sacrificed 4 days after ablation, and the livers were removed for gross and histopathologic analysis.
Effective coagulation volume in the Pringle group (10.8 +/- 5.0 cm(3)) was significantly increased (p = 0.03) compared to the control group (4.1 +/- 4.1 cm(3)). The efficacy ratio, defined as the effective coagulation volume divided by the coagulation volume, was not significantly different in the Pringle group (0.47 +/- 0.27) compared to the control group (0.33 +/- 0.22). The geometrical centre of the effective coagulation volume did not correspond to the position of the ablation electrode. Thermal damage of the gallbladder was found in three animals, all belonging to the Pringle group.
The Pringle manoeuvre was associated with increased effective coagulation volume, but did not significantly influence the predictability of coagulation volume or geometry.
使用带有灌注电极的阻抗控制射频消融系统，评估普林格尔手法对靠近门静脉的凝固灶体积和几何形状的影响。
将12只猪随机分为对照组（n = 6）和在消融过程中应用普林格尔手法的组（n = 6）。每只动物在靠近门静脉处进行一次凝固。所有动物在消融后4天处死，取出肝脏进行大体和组织病理学分析。
与对照组（4.1±4.1 cm³）相比，普林格尔组的有效凝固体积（10.8±5.0 cm³）显著增加（p = 0.03）。普林格尔组的疗效比（定义为有效凝固体积除以凝固体积）与对照组（0.33±0.22）相比无显著差异（0.47±0.27）。有效凝固体积的几何中心与消融电极的位置不对应。在三只动物中发现胆囊热损伤，均属于普林格尔组。
普林格尔手法与有效凝固体积增加有关，但对凝固体积或几何形状的可预测性无显著影响。
