Ruprecht Klemens, Obojes Karola, Wengel Verena, Gronen Felix, Kim Kwang Sik, Perron Hervé, Schneider-Schaulies Jürgen, Rieckmann Peter
Department of Neurology, Clinical Research Unit for Multiple Sclerosis and Neuroimmunology, Würzburg, Germany.
J Neurovirol. 2006 Feb;12(1):65-71. doi: 10.1080/13550280600614973.
The multiple sclerosis-associated retrovirus (MSRV), originally identified in cell cultures from patients with multiple sclerosis (MS), is closely related to the human endogenous retrovirus family W (HERV-W). Recently, HERV-W gag and env protein expression was demonstrated in MS lesions in situ. Here, the authors show that HERV-W gag and env proteins are induced by herpes simplex virus type 1 (HSV-1) in neuronal and brain endothelial cells in vitro. The transactivation of HERV-W proteins by HSV-1 could enhance their potential oligodendrotoxic and immunopathogenic effects, representing a mechanism by which HSV-1, and possibly also other herpesviruses associated with MS, may be linked to the pathogenesis of this disease.
多发性硬化症相关逆转录病毒（MSRV）最初是在多发性硬化症（MS）患者的细胞培养物中发现的，与人类内源性逆转录病毒W家族（HERV-W）密切相关。最近，原位多发性硬化症病变中证实了HERV-W gag和env蛋白的表达。在此，作者表明，在体外，单纯疱疹病毒1型（HSV-1）可在神经元和脑内皮细胞中诱导HERV-W gag和env蛋白。HSV-1对HERV-W蛋白的反式激活可增强其潜在的少突胶质细胞毒性和免疫致病作用，这代表了HSV-1以及可能与MS相关的其他疱疹病毒与该疾病发病机制相关联的一种机制。
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