Prisant L Michael, Spaulding Vernon C
Department of Hypertension & Clinical Pharmacology, Medical College of Georgia, 1470 Harper Street, Augusta, GA 30912, USA.
J Clin Hypertens (Greenwich). 2006 Apr;8(4):296-8. doi: 10.1111/j.1524-6175.2006.05179.x.
Most antihypertensive drugs have known side effects that are elicited by the careful clinician taking care of hypertensive patients. However, many antihypertensive medications utilize drug delivery systems that prolong the duration of blood pressure reduction. The gastrointestinal therapeutic system that is used with nifedipine, isradipine, and verapamil has a unique side effect. Obstruction may occur at the site of a previous surgical repair (pyloric stenosis or gastroplasty) or stenosis of the esophagus, small intestine, or colon. The same delivery system is used with methylphenidate, oxybutynin, glipizide, and doxazosin. Although this complication is rare, physicians who prescribe and care for hypertensive patients should recognize this potential problem.
大多数抗高血压药物都有已知的副作用，细心的临床医生在治疗高血压患者时会引发这些副作用。然而，许多抗高血压药物采用了能延长血压降低持续时间的给药系统。与硝苯地平、伊拉地平、维拉帕米一起使用的胃肠道治疗系统有独特的副作用。在既往手术修复部位（幽门狭窄或胃成形术）或食管、小肠或结肠狭窄处可能发生梗阻。哌甲酯、奥昔布宁、格列吡嗪和多沙唑嗪也使用相同的给药系统。尽管这种并发症很罕见，但开处方和治疗高血压患者的医生应该认识到这个潜在问题。
