Mc Naughton L, Bentley D J, Koeppel P
Department of Sport and Exercise Science, University of Hull, Hull, UK.
J Sports Med Phys Fitness. 2006 Mar;46(1):84-9.
The aim of this work was to determine the ergogenic effects of a nucleotide supplement on salivary immunoglobulin A (SIgA) and cortisol (C) responses after prolonged endurance cycle exercise.
Fourteen moderately trained male subjects (mean body mass and VO2max) completed 2 90-min cycle ergometer trials (60% VO2max) prior to and after 60 days of either a nucleotide (E group, n=7) or placebo (P group, n=7) supplement. Each of the subjects provided an unstimulated saliva sample prior to and following the exercise for determination of SIgA and C.
SIgA was significantly lower after exercise trials in both E and P groups (P<0.0001) prior to as well as after the supplementation period. However, SIgA was significantly higher (P<0.01) in the E group than the P group after supplementation. There were no significant (P>0.11) differences in pre-exercise C level. Postexercise C concentrations were significantly (P<0.001) higher than pre-exercise levels in both groups of subjects. However, after the supplementation period, C concentration was significantly (P<0.0001) lower after exercise in E compared to P.
This work suggests that a nucleotide supplement, given chronically may offset the hormonal response associated with demanding endurance exercise.
本研究旨在确定核苷酸补充剂对长时间耐力自行车运动后唾液免疫球蛋白A（SIgA）和皮质醇（C）反应的促力作用。
14名中度训练的男性受试者（平均体重和最大摄氧量）在补充核苷酸（E组，n = 7）或安慰剂（P组，n = 7）60天之前和之后，完成了2次90分钟的自行车测力计试验（60%最大摄氧量）。每个受试者在运动前后提供未刺激的唾液样本，以测定SIgA和C。
在补充期之前和之后，E组和P组运动试验后的SIgA均显著降低（P < 0.0001）。然而，补充后E组的SIgA显著高于P组（P < 0.01）。运动前C水平无显著差异（P > 0.11）。两组受试者运动后C浓度均显著高于运动前水平（P < 0.001）。然而，在补充期后，E组运动后的C浓度与P组相比显著降低（P < 0.0001）。
本研究表明，长期给予核苷酸补充剂可能会抵消与高强度耐力运动相关的激素反应。
