Daniels Amber L, Van Slambrouck Severine, Lee Robin K, Arguello Tammy S, Browning James, Pullin Michael J, Kornienko Alexander, Steelant Wim F A
Laboratory of Biochemical and Biomedical Research, Department of Chemistry, New Mexico Tech, Socorro, NM 87801, USA.
Oncol Rep. 2006 May;15(5):1327-31.
Native American medicinal plants are traditionally used to prevent and treat a variety of diseases, including cancer. These herbal preparations are alleged to have many biological activities, such as stimulation or suppression of immune responses and antiproliferative effects on cancer cells. In the present study, we investigated the effects of aqueous and ethanol extracts from two Native American plants, Ligusticum porteri (Osha) and Anemopsis californica (Yerba Manza), on the growth of human MCF-7/AZ breast and HCT8/E11 colon cancer cells. The aqueous and ethanol extracts from A. californica potently inhibited growth of MCF-7/AZ in a concentration-dependent manner, whereas the growth of HCT8/E11 was unaltered. Extracts from L. porteri showed no activity on either cell line. In addition, we observed that the extracellular signal-regulated protein kinase 1 and 2 (ERK1/2) activities were markedly decreased when exposed to both extracts from A. californica. These results suggest that the growth inhibitory effect of A. californica in breast cancer cells is ERK-mediated.
美洲原住民传统上使用药用植物来预防和治疗包括癌症在内的多种疾病。据称这些草药制剂具有许多生物活性，如刺激或抑制免疫反应以及对癌细胞的抗增殖作用。在本研究中，我们研究了两种美洲原住民植物波特利藁本（奥夏）和加州银线草（耶尔瓦·曼扎）的水提取物和乙醇提取物对人MCF - 7/AZ乳腺癌细胞和HCT8/E11结肠癌细胞生长的影响。加州银线草的水提取物和乙醇提取物以浓度依赖性方式有效抑制MCF - 7/AZ的生长，而HCT8/E11的生长未改变。波特利藁本的提取物对两种细胞系均无活性。此外，我们观察到，当暴露于加州银线草的两种提取物时，细胞外信号调节蛋白激酶1和2（ERK1/2）的活性显著降低。这些结果表明，加州银线草对乳腺癌细胞的生长抑制作用是由ERK介导的。
