Skrivánková B, Podrazký V, Trnavský K, Julis I
Research Institute for Rheumatic Diseases, Praha, Czechoslovakia.
Methods Find Exp Clin Pharmacol. 1991 Oct;13(8):523-8.
The effects of several antirheumatic drugs on the activity of degradative enzymes in normal and pathologic knee joint cartilage and on the proliferative activity of synovial tissue cells were studied. Inflammatory arthropathy was induced in rabbits by intraarticular papain administration. Elevated contents of proteoglycanase and collagenase, together with an increase in serine and cysteine proteinase inhibitors, were found in animals with papain-induced arthropathy. Inflammation also accelerated the rate of proliferation of cells present in the synovial tissue. In the treated animals, the reduction in enzyme activity, decrease in inhibitor content and decreased DNA proliferation rate were registered to a different degree. The suppression of protein synthesis by nonsteroidal antiinflammatory drugs may explain our findings. The best therapeutic results were achieved with glycosaminoglycan polysulphate (Arteparon).
研究了几种抗风湿药物对正常和病理状态下膝关节软骨中降解酶活性以及滑膜组织细胞增殖活性的影响。通过关节内注射木瓜蛋白酶在兔身上诱发炎性关节病。在木瓜蛋白酶诱发关节病的动物中，发现蛋白聚糖酶和胶原酶含量升高，同时丝氨酸和半胱氨酸蛋白酶抑制剂增加。炎症还加速了滑膜组织中细胞的增殖速率。在接受治疗的动物中，不同程度地记录到酶活性降低、抑制剂含量减少以及DNA增殖速率下降。非甾体抗炎药对蛋白质合成的抑制作用可能解释了我们的研究结果。使用硫酸氨基葡聚糖（Arteparon）取得了最佳治疗效果。
