Vignon E, Mathieu P, Louisot P, Richard M
Department of Rheumatology, Edouard Herriot Hospital, Lyon, France.
Arthritis Rheum. 1991 Oct;34(10):1332-5. doi: 10.1002/art.1780341021.
The effects of several nonsteroidal antiinflammatory drugs, used at concentrations achievable in synovial fluid, on human osteoarthritic (OA) cartilage metallo-protease activity in vitro was studied. Acetaminophen and ketoprofen had no effect; sodium salicylate, indomethacin, and diclofenac slightly decreased proteoglycanase activity. Piroxicam and tenoxicam suppressed proteoglycanase activity by 48.2% and 68.3%, respectively, and suppressed collagenase activity by 19.1% and 36.8%, respectively. Use of these NSAIDs may help to decrease cartilage catabolism in patients with OA.
研究了几种非甾体抗炎药在滑液中可达到的浓度下，对人骨关节炎（OA）软骨金属蛋白酶活性的体外影响。对乙酰氨基酚和酮洛芬无作用；水杨酸钠、吲哚美辛和双氯芬酸可轻微降低蛋白聚糖酶活性。吡罗昔康和替诺昔康分别抑制蛋白聚糖酶活性48.2%和68.3%，并分别抑制胶原酶活性19.1%和36.8%。使用这些非甾体抗炎药可能有助于减少OA患者的软骨分解代谢。
