Evans F J
Department of Pharmacognosy, School of Pharmacy, University of London, U.K.
Planta Med. 1991 Oct;57(7):S60-7.
A brief history of the therapeutic uses and legal problems of cannabis as well as the component cannabinoids is given. This is followed by a discussion of drug development from delta 1-tetrahydrocannabinol and its synthetic analogues. The controversy of whether the pharmacological effects are of central or peripheral origin is included. Then, the potentials for the development of new drugs based on the cannabinoid structure for the treatment of pain, inflammation, and related conditions are outlined. It is concluded that the central activity of cannabinoids is confirmed and that the presence of a C-5 hydroxy group confers potent peripheral activity.
本文介绍了大麻及其成分大麻素的治疗用途和法律问题简史。随后讨论了从δ1-四氢大麻酚及其合成类似物进行药物开发的情况。还包括了关于药理作用是源于中枢还是外周的争议。然后概述了基于大麻素结构开发用于治疗疼痛、炎症及相关病症的新药的潜力。得出的结论是，大麻素的中枢活性得到证实，且C-5羟基的存在赋予了强大的外周活性。
