Matsui M, Kudo T, Kudo M, Ishihara H, Matsuki A
Department of Anesthesiology, University of Hirosaki, School of Medicine.
Agressologie. 1991;32(4):233-5.
To identify the dynamic response of hormones after burns with special reference to ANP during shock and the subsequent period, plasma concentrations of atrial natriuretic peptide (ANP), aldosterone, cortisol, arginine vasopressin (AVP), corticotropin, (ACTH), plasma renin activities (PRA), norepinephrine (NE) and epinephrine (E) were measured from the day of ICU admission and for 7 days following burn injury. Plasma AVP levels were highest on ICU admission and correlated with size of the burn injury ranged from 20-60 percent of the total body surface area. Between the 5th and 6th postburn day plasma ANP levels elevated while plasma AVP levels returned to normal. Urine sodium concentrations decreased from the 3rd day. Plasma aldosterone levels declined after the 2nd day. Mean epinephrine (E) and norepinephrine (NE) levels elevated on admission and remained elevated throughout the study. These results suggest that ANP plays important role for restoring fluid homeostasis by improving edema in burned tissues during refilling periods in burns.
为特别参照休克及随后阶段心钠素（ANP）的情况，确定烧伤后激素的动态反应，自入住重症监护病房（ICU）当日起及烧伤后7天内，测定血浆中心房钠尿肽（ANP）、醛固酮、皮质醇、精氨酸血管加压素（AVP）、促肾上腺皮质激素（ACTH）、血浆肾素活性（PRA）、去甲肾上腺素（NE）和肾上腺素（E）的浓度。血浆AVP水平在入住ICU时最高，且与烧伤面积相关，烧伤面积占体表面积的20%至60%。烧伤后第5天至第6天，血浆ANP水平升高，而血浆AVP水平恢复正常。尿钠浓度从第3天开始下降。血浆醛固酮水平在第2天后下降。入院时平均肾上腺素（E）和去甲肾上腺素（NE）水平升高，且在整个研究过程中一直保持升高。这些结果表明，在烧伤后的补液期，ANP通过改善烧伤组织的水肿，对恢复液体平衡起着重要作用。
