Crum R, Bobrow B, Shackford S, Hansbrough J, Brown M R
Department of Surgery, UCSD Medical Center, San Diego 92103.
J Trauma. 1988 Aug;28(8):1181-7. doi: 10.1097/00005373-198808000-00008.
Fourteen adult patients (mean age, 35 yrs) with 20-60% total body surface area (TBSA) burns (mean, 35%) were resuscitated using hypertonic sodium lactate (HSL: sodium = 250 mEq/L). Plasma concentrations of atrial natriuretic peptide (ANP), arginine vasopressin (AVP), angiotensin II (A-II), epinephrine (E) and norepinephrine (NE) were measured on admission and for 7 days following burn injury. Serum sodium concentrations and osmolalities were lowest on admission, and were persistently elevated following HSL resuscitation. Plasma AVP levels were highest on admission and correlated with the size of the burn injury. Between days 4 and 5 plasma ANP levels rose while plasma AVP levels returned to normal. Plasma concentrations of AVP and ANP did not correlate with serum osmolality or serum sodium concentrations on admission or after HSL resuscitation. Plasma levels of A-II, NE and E were elevated throughout the 7-day period and were unrelated to the size of the burn.
14例成年患者（平均年龄35岁），烧伤面积为总体表面积的20%-60%（平均35%），使用高渗乳酸钠（HSL：钠含量为250 mEq/L）进行复苏。在入院时以及烧伤后7天测量血浆中的心钠素（ANP）、精氨酸加压素（AVP）、血管紧张素II（A-II）、肾上腺素（E）和去甲肾上腺素（NE）浓度。血清钠浓度和渗透压在入院时最低，在HSL复苏后持续升高。血浆AVP水平在入院时最高，且与烧伤面积相关。在第4天至第5天期间，血浆ANP水平升高，而血浆AVP水平恢复正常。入院时或HSL复苏后，血浆AVP和ANP浓度与血清渗透压或血清钠浓度均无相关性。在整个7天期间，血浆A-II、NE和E水平均升高，且与烧伤面积无关。
