一名免疫功能正常女性的暴发性、耐阿昔洛韦的2型单纯疱疹病毒性肝炎
Fulminant, acyclovir-resistant, herpes simplex virus type 2 hepatitis in an immunocompetent woman.
作者信息
Czartoski Todd, Liu Charlie, Koelle David M, Schmechel Stephen, Kalus Andrea, Wald Anna
机构信息
Molecular Virology Laboratory, University of Washington, 960 Republican St., Seattle, WA 98195, USA.
出版信息
J Clin Microbiol. 2006 Apr;44(4):1584-6. doi: 10.1128/JCM.44.4.1584-1586.2006.
Abstract
We report an immunocompetent woman with multisystem organ failure following herpes simplex virus type 2 (HSV-2) hepatitis. After she initially responded to intravenous acyclovir, she was switched to oral valacyclovir. She developed respiratory failure and opportunistic infections and died. Autopsy confirmed disseminated HSV infection, and lung tissue grew acyclovir-resistant HSV-2.
摘要
我们报告了一例免疫功能正常的女性，其在感染2型单纯疱疹病毒（HSV-2）后出现多系统器官衰竭。她最初对静脉注射阿昔洛韦有反应，之后改为口服伐昔洛韦。她出现了呼吸衰竭和机会性感染并死亡。尸检证实存在播散性HSV感染，且肺组织培养出对阿昔洛韦耐药的HSV-2。
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