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Clinical characteristics and significance of Streptococcus salivarius bacteremia and Streptococcus bovis bacteremia: a prospective 16-year study.唾液链球菌菌血症和牛链球菌菌血症的临床特征及意义：一项为期16年的前瞻性研究
Eur J Clin Microbiol Infect Dis. 2005 Apr;24(4):250-5. doi: 10.1007/s10096-005-1314-x.
2
The rationale and potential for the reduction of oral malodour using Streptococcus salivarius probiotics.使用唾液链球菌益生菌减少口腔异味的原理及潜力。
Oral Dis. 2005;11 Suppl 1:29-31. doi: 10.1111/j.1601-0825.2005.01084.x.
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Pathogenic relevance of Lactobacillus: a retrospective review of over 200 cases.乳酸杆菌的致病相关性：200余例病例的回顾性研究
Eur J Clin Microbiol Infect Dis. 2005 Jan;24(1):31-40. doi: 10.1007/s10096-004-1253-y.
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Complete sequence and comparative genome analysis of the dairy bacterium Streptococcus thermophilus.嗜热链球菌的全序列及比较基因组分析
Nat Biotechnol. 2004 Dec;22(12):1554-8. doi: 10.1038/nbt1034. Epub 2004 Nov 14.
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Antimicrobial susceptibility of viridans group streptococcal blood isolates to eight antimicrobial agents.草绿色链球菌血培养分离株对八种抗菌药物的药敏试验
Scand J Infect Dis. 2004;36(4):259-63. doi: 10.1080/00365540410019435.
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Carcinoma of the colon presenting as Streptococcus salivarius sepsis.以唾液链球菌败血症为表现的结肠癌
J Clin Gastroenterol. 2004 Jan;38(1):86-7. doi: 10.1097/00004836-200401000-00021.
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Viridans streptococcus bacteremia in children on chemotherapy for cancer: an underestimated problem.接受癌症化疗的儿童中的草绿色链球菌菌血症：一个被低估的问题。
Pediatr Hematol Oncol. 2003 Sep;20(6):439-44.
8
Enterococci in foods--a conundrum for food safety.食品中的肠球菌——食品安全的一个难题。
Int J Food Microbiol. 2003 Dec 1;88(2-3):105-22. doi: 10.1016/s0168-1605(03)00174-0.
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Bacterial replacement therapy: adapting 'germ warfare' to infection prevention.细菌替代疗法：将“细菌战”应用于感染预防
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Three cases of bacterial meningitis after spinal and epidural anesthesia.三例脊髓和硬膜外麻醉后细菌性脑膜炎病例。
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口腔益生菌唾液链球菌K12的安全性评估

Safety assessment of the oral cavity probiotic Streptococcus salivarius K12.

作者信息

Burton Jeremy P, Wescombe Philip A, Moore Chris J, Chilcott Chris N, Tagg John R

机构信息

BLIS Technologies, Centre for Innovation, University of Otago, P.O. Box 56, Dunedin, New Zealand.

出版信息

Appl Environ Microbiol. 2006 Apr;72(4):3050-3. doi: 10.1128/AEM.72.4.3050-3053.2006.

DOI:10.1128/AEM.72.4.3050-3053.2006
PMID:16598017
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1449041/
Abstract

Streptococcus salivarius is a prominent member of the oral microbiota and has excellent potential for use as a probiotic targeting the oral cavity. In this report we document safety data relating to S. salivarius K12, including assessment of its antibiogram, metabolic profiles, and virulence determinants, and we examine the microbial composition of saliva following the dosing of subjects with K12.

摘要

唾液链球菌是口腔微生物群的重要成员，作为一种针对口腔的益生菌具有巨大的应用潜力。在本报告中，我们记录了与唾液链球菌K12相关的安全性数据，包括其抗菌谱、代谢谱和毒力决定因素的评估，并研究了给受试者服用K12后唾液中的微生物组成。