Medikor, Department of Nutrition, Zagreb, Croatia.
Institution for Home Healthcare Domnius, Zagreb, Croatia.
Probiotics Antimicrob Proteins. 2017 Jun;9(2):102-110. doi: 10.1007/s12602-017-9261-2.
Traditionally, probiotics are linked to the good health of the intestine and most clinical studies focus on that field. Evidence of oral probiotic use for ear and oral cavity disease prevention with impact on human health is limited. This work reviews existing studies and literature on Streptococcus salivarius K12 as an oral probiotic and effects of S. salivarius K12 on human ear and oral cavity human health. The studies were accessed via database searches: MEDLINE, PubMed, and Elsevier. The search included/focused on/encompassed publications from 2003 to 2016 with keywords related to K12 Streptococcus salivarius, bacteriocin-like inhibitory substances (BLIS) K12, probiotic K12 salivarius, and K12 probiotic health effects. Only a small amount of studies was identified: the total of 68 studies was identified, 35 of which were relevant after screening, and 9 were included in the final analysis. Very little literature is available about the association/correlation between/connection/interrelation of S. salivarius K12 with/and human ear and oral cavity health. S. salivarius K12 may have a role in reducing the occurrence and/or severity of secretory otitis media (SOM) and also in prevention of streptococcal and viral pharyngotonsillitis in children. Research highlights that S. salivarius K12 has shown promising results in treatment of halitosis, but data are still deficient. Further studies need to be initiated to improve understanding of the association of oral probiotic S. salivarius K12 with human ear and oral cavity health.
传统上，益生菌与肠道健康有关，大多数临床研究都集中在这一领域。有证据表明，口腔益生菌可预防耳部和口腔疾病，从而对人类健康产生影响，但目前这方面的证据有限。本研究综述了现有关于唾液链球菌 K12 作为口腔益生菌的研究和文献，并探讨了 S. salivarius K12 对人类耳部和口腔健康的影响。通过数据库检索获取研究资料：MEDLINE、PubMed 和 Elsevier。检索词包括 K12 唾液链球菌、细菌素样抑制物质（BLIS）K12、益生菌 K12 唾液链球菌和 K12 益生菌的健康影响。仅确定了少量研究：共确定了 68 项研究，筛选后有 35 项相关，最终有 9 项纳入分析。关于 S. salivarius K12 与人类耳部和口腔健康之间的关联/相关性、联系/相互关系的文献非常少。S. salivarius K12 可能在降低分泌性中耳炎（SOM）的发生和/或严重程度以及预防儿童链球菌性和病毒性咽扁桃体炎方面发挥作用。研究结果表明，S. salivarius K12 在治疗口臭方面显示出良好的效果，但数据仍然不足。需要进一步开展研究，以加深对口腔益生菌 S. salivarius K12 与人类耳部和口腔健康之间关联的认识。
