• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Small vessels, big problems.

作者信息

Greenberg Steven M

机构信息

Neurology Clinical Trials Unit, Massachusetts General Hospital, Boston, USA.

出版信息

N Engl J Med. 2006 Apr 6;354(14):1451-3. doi: 10.1056/NEJMp068043.

DOI:10.1056/NEJMp068043
PMID:16598043
Abstract
摘要

相似文献

1
Small vessels, big problems.小血管,大问题。
N Engl J Med. 2006 Apr 6;354(14):1451-3. doi: 10.1056/NEJMp068043.
2
Role of COL4A1 in small-vessel disease and hemorrhagic stroke.COL4A1在小血管疾病和出血性卒中中的作用。
N Engl J Med. 2006 Apr 6;354(14):1489-96. doi: 10.1056/NEJMoa053727.
3
Fragile vessels: handle with care.
Neurology. 2007 Oct 16;69(16):1560-1. doi: 10.1212/01.wnl.0000295992.00845.5a.
4
Mutations in Col4a1 cause perinatal cerebral hemorrhage and porencephaly.Col4a1基因的突变会导致围产期脑出血和脑穿通畸形。
Science. 2005 May 20;308(5725):1167-71. doi: 10.1126/science.1109418.
5
Clinical and brain MRI follow-up study of a family with COL4A1 mutation.一项关于COL4A1基因突变家族的临床及脑部磁共振成像随访研究
Neurology. 2007 Oct 16;69(16):1564-8. doi: 10.1212/01.wnl.0000295994.46586.e7.
6
[HANAC syndrome (hereditary angiopathy with nephropathy, aneurysms and muscle cramps) and mutations of the collagen 4A1 gene: a new basement membrane hereditary pathology with multisystemic expression].[HANAC综合征(伴有肾病、动脉瘤和肌肉痉挛的遗传性血管病)与胶原蛋白4A1基因的突变:一种具有多系统表现的新型基底膜遗传性疾病]
Nephrol Ther. 2008 Dec;4(7):632-4. doi: 10.1016/j.nephro.2008.03.013. Epub 2008 Sep 24.
7
Role of COL4A1 in basement-membrane integrity and cerebral small-vessel disease. The COL4A1 stroke syndrome.COL4A1 在基底膜完整性和脑小血管疾病中的作用。COL4A1 中风综合征。
Curr Med Chem. 2010;17(13):1317-24. doi: 10.2174/092986710790936293.
8
Molecular and Genetic Analyses of Collagen Type IV Mutant Mouse Models of Spontaneous Intracerebral Hemorrhage Identify Mechanisms for Stroke Prevention.自发性脑出血的IV型胶原突变小鼠模型的分子和遗传分析确定了预防中风的机制。
Circulation. 2015 May 5;131(18):1555-65. doi: 10.1161/CIRCULATIONAHA.114.013395. Epub 2015 Mar 9.
9
COL4A1 mutation revealed by an isolated brain hemorrhage.孤立性脑出血揭示的COL4A1突变
Cerebrovasc Dis. 2013;35(6):593-4. doi: 10.1159/000351520. Epub 2013 Jul 10.
10
Intracerebral hemorrhage and COL4A1 mutations, from preterm infants to adult patients.从早产儿到成年患者的脑出血与COL4A1突变
Ann Neurol. 2009 Jan;65(1):1-2. doi: 10.1002/ana.21607.

引用本文的文献

1
A novel MRI-based deep learning imaging biomarker for comprehensive assessment of the lenticulostriate artery-neural complex.一种基于磁共振成像的新型深度学习成像生物标志物,用于全面评估豆纹动脉-神经复合体。
BMC Med Imaging. 2025 May 26;25(1):191. doi: 10.1186/s12880-025-01676-3.
2
Umbelliferone as an effective component of Rhodiola for protecting the cerebral microvascular endothelial barrier in cSVD.伞形花内酯作为红景天的有效成分,用于保护慢性脑小血管病中的脑微血管内皮屏障。
Front Pharmacol. 2025 Mar 17;16:1552579. doi: 10.3389/fphar.2025.1552579. eCollection 2025.
3
Stand-alone segmentation of blood flow pulsatility measured with diffuse correlation spectroscopy.
用扩散相关光谱法测量的血流搏动性的独立分割
Biomed Opt Express. 2024 Sep 26;15(10):6052-6062. doi: 10.1364/BOE.533916. eCollection 2024 Oct 1.
4
Enlarged perivascular space burden predicts declines in cognitive and functional performance.血管周围间隙扩大负担预测认知和功能表现下降。
J Neurol Sci. 2024 Nov 15;466:123232. doi: 10.1016/j.jns.2024.123232. Epub 2024 Sep 12.
5
Cerebrovascular reactivity MRI as a biomarker for cerebral small vessel disease-related cognitive decline: Multi-site validation in the MarkVCID Consortium.磁共振脑血管反应性成像作为与脑小血管病相关认知衰退的生物标志物:MarkVCID 联盟的多中心验证。
Alzheimers Dement. 2024 Aug;20(8):5281-5289. doi: 10.1002/alz.13888. Epub 2024 Jul 1.
6
Exploring the neuroprotective role of physical activity in cerebral small vessel disease.探讨身体活动在脑小血管病中的神经保护作用。
Brain Res. 2024 Jun 15;1833:148884. doi: 10.1016/j.brainres.2024.148884. Epub 2024 Mar 23.
7
Relationship between chronic kidney disease and cerebral white matter hyperintensities: a systematic review.慢性肾脏病与脑白质高信号之间的关系:一项系统评价
Quant Imaging Med Surg. 2023 Nov 1;13(11):7596-7606. doi: 10.21037/qims-22-707. Epub 2023 Jan 2.
8
Fibrinogen in mice cerebral microvessels induces blood-brain barrier dysregulation with aging via a dynamin-related protein 1-dependent pathway.小鼠脑微血管中的纤维蛋白原通过一种与动力蛋白相关蛋白 1 相关的途径诱导血脑屏障随年龄增长而失调。
Geroscience. 2024 Feb;46(1):395-415. doi: 10.1007/s11357-023-00988-y. Epub 2023 Oct 28.
9
Regional white matter hyperintensity volume predicts persistent cognitive impairment in acute lacunar infarct patients.局部白质高信号体积可预测急性腔隙性脑梗死患者的持续性认知障碍。
Front Neurol. 2023 Oct 10;14:1265743. doi: 10.3389/fneur.2023.1265743. eCollection 2023.
10
Dependence of resting-state-based cerebrovascular reactivity (CVR) mapping on spatial resolution.基于静息状态的脑血管反应性(CVR)映射对空间分辨率的依赖性。
Front Neuroimaging. 2023 Jun 26;2:1205459. doi: 10.3389/fnimg.2023.1205459. eCollection 2023.