Leichman J G, Lavis V R, Aguilar D, Wilson C R, Taegtmeyer H
The University of Texas Houston Medical School, Department of Internal Medicine, Division of Cardiology, 6431 Fannin Street, MSB 1.246, Houston, TX 77030, USA.
Clin Res Cardiol. 2006 Jan;95 Suppl 1:i134-41. doi: 10.1007/s00392-006-1119-7.
The metabolic syndrome (MS) is a multifactorial, heterogeneous group of risk factors for the development of cardiovascular disease. Here we review the evidence in support of the hypothesis that metabolic dysregulation of the body as a whole leads to contractile dysfunction of the heart due to an imbalance of substrate uptake (increased) and substrate oxidation (decreased). The consequences of this imbalance were already recognized 150 years ago by Virchow when he described "fatty atrophy" of the heart as a "true metamorphosis of the heart muscle cell."
代谢综合征（MS）是一组导致心血管疾病发生的多因素、异质性危险因素。在此，我们回顾相关证据，以支持以下假说：由于底物摄取（增加）与底物氧化（减少）失衡，机体整体代谢失调会导致心脏收缩功能障碍。150年前，魏尔啸就已认识到这种失衡的后果，当时他将心脏的“脂肪性萎缩”描述为“心肌细胞的真正变形”。
