Liu Chia-Yu, Wang Mao-Che, Li Wing-Yin, Chang Shyue-Yi, Chu Pen-Yuan
Department of Otolaryngology, Taipei Veterans General Hospital, and National Tang-Ming University School of Medicine, Taipei, Taiwan, ROC.
J Chin Med Assoc. 2006 Mar;69(3):120-4. doi: 10.1016/S1726-4901(09)70189-3.
Sarcomas of the larynx are rare neoplasms that constitute less than 1% of laryngeal malignancies. A Medline search found no large series focusing on laryngeal sarcomas. We reviewed the cases of laryngeal sarcomas treated in our cancer center and compared our experiences and treatment results with those from other centers.
A retrospective review of 10 patients with laryngeal sarcoma treated in our institute between 1980 and 2000 was done to identify tumor characteristics, therapeutic modalities, and treatment outcomes.
The patients showed a male predominance (9/10) and presented 8 types of pathology. Nine patients underwent surgery, including 2 total laryngectomy, 4 partial laryngectomy, and 3 endoscopic laser cordectomy. During a median follow-up of 92 months, the 5-year overall survival and disease-specific survival were 76% and 90%, respectively. Two patients developed recurrence, including 1 local recurrence and 1 distant metastasis.
Surgical intervention was the first choice in the treatment of laryngeal sarcomas. The prognosis is relatively good when compared with sarcoma originating from other anatomic sites.
喉肉瘤是罕见肿瘤，占喉恶性肿瘤的比例不到1%。医学文献数据库检索未发现聚焦于喉肉瘤的大型系列研究。我们回顾了在我们癌症中心治疗的喉肉瘤病例，并将我们的经验和治疗结果与其他中心的进行了比较。
对1980年至2000年间在我院接受治疗的10例喉肉瘤患者进行回顾性研究，以确定肿瘤特征、治疗方式和治疗结果。
患者以男性为主（9/10），呈现8种病理类型。9例患者接受了手术，包括2例全喉切除术、4例部分喉切除术和3例内镜激光声带切除术。中位随访92个月时，5年总生存率和疾病特异性生存率分别为76%和90%。2例患者出现复发，包括1例局部复发和1例远处转移。
手术干预是喉肉瘤治疗的首选。与起源于其他解剖部位的肉瘤相比，其预后相对较好。
