Gao Chao, Li Wenwen, Morimoto Hisao, Nagaoka Yutaka, Maekawa Toru
College of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China.
J Phys Chem B. 2006 Apr 13;110(14):7213-20. doi: 10.1021/jp0602474.
Magnetic multiwalled carbon nanotubes (MWNTs) were facilely prepared by the electrostatic self-assembly approach. Poly(2-diethylaminoethyl methacrylate) (PDEAEMA) was covalently grafted onto the surfaces of MWNTs by MWNT-initiated in situ atom transfer radical polymerization (ATRP) of 2-diethylaminoethyl methacrylate (DEAEMA). The PDEAEMA-grafted MWNTs were quaternized with methyl iodide (CH(3)I), resulting in cationic polyelectrolyte-grafted MWNTs (MWNT-PAmI). Magnetic iron oxide (Fe(3)O(4)) nanoparticles were loaded onto the MWNT surfaces by electrostatic self-assembling between MWNT-PAmI and Fe(3)O(4), affording magnetic nanotubes. The assembled capability of the nanoparticles can be adjusted to some extent by changing the feed ratio of Fe(3)O(4) to MWNT-PAmI. The obtained magnetic nanotubes were characterized with TEM, EDS, STEM, and element mapping analyses. TEM and EDS measurements confirmed the nanostructures and the components of the resulting nanoobjects. The magnetic nanotubes were assembled onto sheep red blood cells in a phosphate buffer solution, forming magnetic cells. The blood cells attached with or without magnetic nanotubes can be selectively manipulated in a magnetic field. These results promise a general and efficient strategy to magnetic nanotubes and the fascinating potential of such magnetic nanoobjects in applications of bionanoscience and technology.
通过静电自组装方法轻松制备了磁性多壁碳纳米管（MWNTs）。通过2-二乙氨基乙基甲基丙烯酸酯（DEAEMA）的MWNT引发原位原子转移自由基聚合（ATRP），将聚（2-二乙氨基乙基甲基丙烯酸酯）（PDEAEMA）共价接枝到MWNTs表面。用甲基碘（CH(3)I）将接枝了PDEAEMA的MWNTs季铵化，得到阳离子聚电解质接枝的MWNTs（MWNT-PAmI）。通过MWNT-PAmI与Fe(3)O(4)之间的静电自组装，将磁性氧化铁（Fe(3)O(4)）纳米颗粒负载到MWNT表面，得到磁性纳米管。通过改变Fe(3)O(4)与MWNT-PAmI的进料比，可以在一定程度上调节纳米颗粒的组装能力。用透射电子显微镜（TEM）、能谱仪（EDS）、扫描透射电子显微镜（STEM）和元素映射分析对所得磁性纳米管进行了表征。TEM和EDS测量证实了所得纳米物体的纳米结构和成分。在磷酸盐缓冲溶液中，将磁性纳米管组装到绵羊红细胞上，形成磁性细胞。带有或不带有磁性纳米管的血细胞可以在磁场中被选择性地操控。这些结果为制备磁性纳米管提供了一种通用且有效的策略，并展示了此类磁性纳米物体在生物纳米科学与技术应用中的迷人潜力。
