Dore-Duffy P, Donovan C
Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan 48201.
Clin Immunol Immunopathol. 1991 Oct;61(1):119-28. doi: 10.1016/s0090-1229(06)80012-7.
We previously showed that monocytes from patients with multiple sclerosis (MS) produce increased prostaglandin E (PGE) in tissue culture. In this paper we show that monocytes from patients with chronic progressive MS are less sensitive to agents which stimulate PGE synthesis than healthy controls. MS cells are equally sensitive to PG inhibitors. MS monocytes have increased levels of cellular cyclic AMP and are less sensitive to PGE-mediated increases in cAMP. Depressed monocyte natural cytotoxicity was found to be correlated with cellular cAMP. Functional desensitization of monocytes and decreased sensitivity to PGE signals may be related to chronic exposure to prostaglandin E.
我们之前发现，多发性硬化症（MS）患者的单核细胞在组织培养中产生的前列腺素E（PGE）增多。在本文中，我们发现，慢性进展型MS患者的单核细胞对刺激PGE合成的试剂的敏感性低于健康对照。MS细胞对PG抑制剂同样敏感。MS单核细胞的细胞内环磷酸腺苷（cAMP）水平升高，对PGE介导的cAMP升高的敏感性降低。单核细胞自然细胞毒性降低与细胞cAMP相关。单核细胞的功能脱敏和对PGE信号的敏感性降低可能与长期暴露于前列腺素E有关。
