Dore-Duffy P, Donaldson J O, Koff T, Longo M, Perry W
Neurology. 1986 Dec;36(12):1587-90. doi: 10.1212/wnl.36.12.1587.
Release of prostaglandin E (PGE) was examined in leukocyte cultures from patients with definite MS who had had at least one recent exacerbation, others with chronic progressive or stable MS, and healthy controls. MS patients had higher baseline levels of PGE than did controls. Patients with active symptoms exhibited a sharp increase in PGE release early in or just before the onset of clinical symptoms. Levels dropped early in exacerbation immediately after the burst in PGE synthesis activity. Values gradually increased to control levels and then to preexacerbation levels. Similar rises and falls were not seen in stable MS. MS patients may have a circulating population of activated leukocytes that produce PGE.
在近期至少有一次病情加重的明确多发性硬化症（MS）患者、慢性进展性或稳定型MS患者以及健康对照者的白细胞培养物中检测了前列腺素E（PGE）的释放情况。MS患者的PGE基线水平高于对照组。有活动症状的患者在临床症状出现早期或即将出现之前，PGE释放急剧增加。在PGE合成活性爆发后，病情加重早期水平下降。数值逐渐升至对照水平，然后升至病情加重前水平。稳定型MS患者未观察到类似的上升和下降情况。MS患者可能有一群循环的活化白细胞产生PGE。
