Jacques T S, Eldridge C, Patel A, Saleem N M, Powell M, Kitchen N D, Thom M, Revesz T
Division of Neuropathology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.
Neuropathol Appl Neurobiol. 2006 Apr;32(2):217-20. doi: 10.1111/j.1365-2990.2005.00692.x.
We describe three unusual tumours characterized by a mixture of glial and neuronal differentiation, involvement of the posterior fossa and formation of rosettes. Mixed glial-neuronal tumours of the posterior fossa are rare and poorly described neoplasms. However, several distinctive entities have appeared in the literature over recent years under a variety of different names. Our cases demonstrate the morphological features of the 'rosette-forming glioneuronal tumour of the fourth ventricle', a recently identified tumour characterised by its unique location, neurocytic pseudo-rosette formation and the presence of a low grade astrocytoma component. The long term prognosis of these tumours remains unclear. However, the clinical data available including the cases presented here, along with the histological features, suggest that these are low grade tumours with a good prognosis after surgical resection.
我们描述了三种不寻常的肿瘤,其特征为具有神经胶质和神经元分化的混合表现、累及后颅窝并形成菊形团。后颅窝混合性神经胶质-神经元肿瘤是罕见且描述甚少的肿瘤。然而,近年来文献中出现了几种以各种不同名称命名的独特实体。我们的病例展示了“第四脑室菊形团形成性神经胶质神经元肿瘤”的形态学特征,这是一种最近发现的肿瘤,其特点是独特的位置、神经细胞性假菊形团形成以及存在低级别星形细胞瘤成分。这些肿瘤的长期预后仍不清楚。然而,现有的临床数据,包括此处呈现的病例,以及组织学特征表明,这些是低级别肿瘤,手术切除后预后良好。