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驱蚊剂和超华法林灭鼠剂——它们对儿童真的有毒吗?

Mosquito repellents and superwarfarin rodenticides--are they really toxic in children?

作者信息

Kendrick Dawn Boudrow

机构信息

Division of Pediatric Emergency Medicine, Department of Pediatrics, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama 35233, USA.

出版信息

Curr Opin Pediatr. 2006 Apr;18(2):180-3. doi: 10.1097/01.mop.0000193273.54742.6f.

DOI:10.1097/01.mop.0000193273.54742.6f
PMID:16601500
Abstract

PURPOSE OF REVIEW

In many United States households, there are many substances used to control the exposure of our children to mosquitoes, mice and rats. This review provides information on common mosquito repellents and rodenticides used in households and discusses their toxicity, in order to help pediatricians better advise their patients of their proper use.

RECENT FINDINGS

A recent study has demonstrated that many continue to have practices of applying DEET (N,N-diethyl-3-methylbenzamide) based repellents that may lead to undesirable effects. Picaridin and oil of lemon eucalyptus are two products that have recently been shown to have an efficacy similar to that of DEET-based repellents. Studies within the last five years show that most unintentional superwarfarin ingestions can be managed at home with close outpatient follow-up. There does not appear to be a benefit of prophylactic vitamin K or gastrointestinal decontamination in patients with relatively small ingestions of superwarfarins.

SUMMARY

With education and correct usage, mosquito repellents and the superwarfarin rodenticides can help protect children from significant vector-borne diseases. Not all exposures lead to significant morbidity or mortality. With recognition of the current literature, most of these exposures can be managed safely at home or as an outpatient, ultimately saving healthcare costs.

摘要

综述目的

在美国的许多家庭中,有多种物质用于控制儿童接触蚊子、老鼠。本综述提供了家庭中常用驱蚊剂和灭鼠剂的信息,并讨论了它们的毒性,以帮助儿科医生更好地指导患者正确使用。

最新发现

最近一项研究表明,许多人继续使用含有避蚊胺(N,N-二乙基-3-甲基苯甲酰胺)的驱蚊剂,这可能会导致不良影响。派卡瑞丁和柠檬桉叶油是最近被证明具有与含避蚊胺驱蚊剂相似功效的两种产品。过去五年的研究表明,大多数意外摄入超级华法林的情况可在门诊密切随访下在家中处理。对于摄入相对少量超级华法林的患者,预防性使用维生素K或进行胃肠道去污似乎并无益处。

总结

通过教育和正确使用,驱蚊剂和超级华法林灭鼠剂可以帮助保护儿童免受重大媒介传播疾病的侵害。并非所有接触都会导致严重的发病或死亡。了解当前文献后,大多数此类接触可在家中或门诊安全处理,最终节省医疗费用。

相似文献

1
Mosquito repellents and superwarfarin rodenticides--are they really toxic in children?驱蚊剂和超华法林灭鼠剂——它们对儿童真的有毒吗?
Curr Opin Pediatr. 2006 Apr;18(2):180-3. doi: 10.1097/01.mop.0000193273.54742.6f.
2
Insect repellents: historical perspectives and new developments.驱虫剂:历史视角与新进展
J Am Acad Dermatol. 2008 May;58(5):865-71. doi: 10.1016/j.jaad.2007.10.005. Epub 2008 Feb 13.
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Risk assessments for the insect repellents DEET and picaridin.驱蚊剂避蚊胺和派卡瑞丁的风险评估。
Regul Toxicol Pharmacol. 2008 Jun;51(1):31-6. doi: 10.1016/j.yrtph.2008.03.002. Epub 2008 Mar 18.
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Human Exposures to N,N-diethyl-m-toluamide insect repellents reported to the American Association of Poison Control Centers 1993-1997.1993年至1997年向美国毒物控制中心协会报告的人类接触N,N - 二乙基间甲苯酰胺驱虫剂的情况。
Int J Toxicol. 2002 Sep-Oct;21(5):341-52. doi: 10.1080/10915810290096559.
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Accidental poisoning with a superwarfarin compound (brodifacoum) in a child.一名儿童意外中毒,摄入了一种超级华法林化合物(溴敌隆)。
Pediatrics. 1990 Dec;86(6):883-7.
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A prospective study of acute, unintentional, pediatric superwarfarin ingestions managed without decontamination.一项关于未经去污处理的急性、非故意儿童超华法林摄入情况的前瞻性研究。
Ann Emerg Med. 2002 Jul;40(1):73-8. doi: 10.1067/mem.2002.125449.
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Exposure of children to Deet and other topically applied insect repellents.儿童接触避蚊胺及其他局部使用的驱虫剂。
Am J Ind Med. 2005 Jan;47(1):91-7. doi: 10.1002/ajim.20114.
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Toxic encephalopathy associated with use of DEET insect repellents: a case analysis of its toxicity in children.与避蚊胺驱虫剂使用相关的中毒性脑病:儿童中毒病例分析
Hum Exp Toxicol. 2001 Jan;20(1):8-14. doi: 10.1191/096032701676731093.
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The toxicity of picaridin containing insect repellent reported to the National Poison Data System.含派卡瑞丁的驱虫剂的毒性已上报至国家中毒数据系统。
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Coagulopathy associated with superwarfarin exposure.与超级华法林暴露相关的凝血病。
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引用本文的文献

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Childhood Ingestions of Environmental Toxins: What Are the Risks?儿童摄入环境毒素:风险有哪些?
Pediatr Ann. 2017 Dec 1;46(12):e466-e471. doi: 10.3928/19382359-20171116-01.
2
Synergy between repellents and organophosphates on bed nets: efficacy and behavioural response of natural free-flying An. gambiae mosquitoes.驱避剂与有机磷农药在蚊帐中的协同作用:自然自由飞行的冈比亚按蚊的功效和行为反应。
PLoS One. 2009 Nov 19;4(11):e7896. doi: 10.1371/journal.pone.0007896.
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Mixture for controlling insecticide-resistant malaria vectors.用于控制抗杀虫剂疟疾媒介的混合物。
Emerg Infect Dis. 2008 Nov;14(11):1707-14. doi: 10.3201/eid1411.071575.