Aizikov Konstantin, O'Connor Peter B
Mass Spectrometry Resource, Department of Biochemistry, Boston University School of Medicine, 02118, Boston, MA, USA.
the Cardiovascular Proteomics Center, Boston University School of Medicine, Boston, MA.
J Am Soc Mass Spectrom. 2006 Jun;17(6):836-843. doi: 10.1016/j.jasms.2006.02.018. Epub 2006 Apr 17.
The filter diagonalization method (FDM) is a recently developed computational technique capable of extracting resonance frequencies and amplitudes from very short transient signals. Although it requires stable resonance frequencies and is slower than the fast Fourier transform (FFT), FDM has a resolution and accuracy that is unmatched by the FFT or any other comparable techniques. This unique feature of FDM makes it an ideal tool for tracing space charge induced frequency modulations in Fourier transform ion cyclotron resonance (FT-ICR) cells, which are shown to reach +/-400 ppm even for such simple spectra as Substance P.
滤波器对角化方法（FDM）是一种最近开发的计算技术，能够从非常短的瞬态信号中提取共振频率和振幅。尽管它需要稳定的共振频率，并且比快速傅里叶变换（FFT）慢，但FDM具有FFT或任何其他可比技术无法比拟的分辨率和精度。FDM的这一独特特性使其成为追踪傅里叶变换离子回旋共振（FT-ICR）池中空间电荷诱导的频率调制的理想工具，即使对于诸如P物质这样简单的光谱，FT-ICR池中显示的频率调制也能达到±400 ppm。
