伊朗的寻常型天疱疮：流行病学与临床特征
Pemphigus vulgaris in Iran: epidemiology and clinical profile.
作者信息
Asilian Ali, Yoosefi Alireza, Faghini Gita
机构信息
Department of Dermatology, Alzahra University Hospital, Isfahan University School of Medicine, Isfahan, Iran.
出版信息
Skinmed. 2006 Mar-Apr;5(2):69-71. doi: 10.1111/j.1540-9740.2006.03756.x.
BACKGROUND
Although the clinical profile of pemphigus vulgaris is generally well characterized, the epidemiologic differences are important but not widely evaluated. This study was conducted to evaluate the incidence and clinical profile of pemphigus patients in a large central province of Iran.
METHODS
Demographic variables, clinical manifestations, and side effects of treatment in 188 patients in a 10-year period were studied.
RESULTS
The annual incidence rate of pemphigus vulgaris was 5/100,000, with a 1.6:1 ratio of incidence in women compared with men. The mean age of onset was 41.1+/-13.7 years. In 74% of patients, the initial presentation of the disease was mucosal involvement, and in the remaining 26% the disease initially presented on the skin.
CONCLUSIONS
Iranian patients have a relatively young age of onset of pemphigus and a higher incidence among women than men, which may reflect geographic, cultural, dietetic, or racial differences in the clinical and biologic behavior of the disease.
背景
尽管寻常型天疱疮的临床特征通常已得到充分描述，但流行病学差异很重要却未得到广泛评估。本研究旨在评估伊朗一个中部大省天疱疮患者的发病率及临床特征。
方法
对188例患者在10年期间的人口统计学变量、临床表现及治疗副作用进行了研究。
结果
寻常型天疱疮的年发病率为5/100,000，女性与男性的发病率之比为1.6:1。发病的平均年龄为41.1±13.7岁。74%的患者疾病最初表现为黏膜受累，其余26%的患者疾病最初表现在皮肤上。
结论
伊朗患者天疱疮的发病年龄相对较轻，女性发病率高于男性，这可能反映了该疾病在临床和生物学行为方面的地理、文化、饮食或种族差异。
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