Fallah Maryam, Najafi Anahita, Ranjbar Mahsa, Balighi Kamran, Daneshpazhooh Maryam, Ebrahimpour-Koujan Soraiya
From the Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Indian J Dermatol. 2025 Mar-Apr;70(2):63-74. doi: 10.4103/ijd.ijd_372_24. Epub 2025 Feb 27.
There is little evidence about the relationship between lipid indices and the severity of pemphigus vulgaris (PV) disease. In this cross-sectional study, we try to find out the exact relationship between three dietary lipid indices (PUFA/SFA ratio and ω-6/ω-3 index) and the severity of PV disease.
In this hospital-based cross-sectional study, a total of 138 pemphigus vulgaris cases were studied, of which 108 had PDAI ≤15, and 30 had PDAI>15. Dietary intakes were measured a valid 168-item FFQ. To calculate the lipid indices, the data received from diet were used.
After adjusting for potential confounders, people with the highest ω-6/ω-3 index had 32% lowest severity of PV disease compared to the people in the lowest category. However, this association was not significant in all models (OR: 0.68; 95% CI: 0.24-1.93, = 0.47). Moreover, people with the highest PUFA/SFA index had 9% highest severity of PV disease compared to the people in the lowest category. However, this association was not significant in all models (OR: 1.09; 95% CI: 0.34-3.51, = 0.88).
The evidence of our study shows that the relation between PUFA/SFA ratio and ω-6/ω-3 index is not significant. However, case-control studies are needed to confirm these findings.
关于脂质指标与寻常型天疱疮（PV）疾病严重程度之间的关系，几乎没有证据。在这项横断面研究中，我们试图找出三种饮食脂质指标（多不饱和脂肪酸/饱和脂肪酸比值和ω-6/ω-3指数）与PV疾病严重程度之间的确切关系。
在这项基于医院的横断面研究中，共研究了138例寻常型天疱疮病例，其中108例患者的天疱疮疾病活动指数（PDAI）≤15，30例患者的PDAI>15。通过一份有效的包含168个条目的食物频率问卷来测量饮食摄入量。利用从饮食中获取的数据来计算脂质指标。
在对潜在混杂因素进行调整后，与处于最低类别者相比，ω-6/ω-3指数最高的人群PV疾病严重程度低32%。然而，在所有模型中这种关联并不显著（比值比：0.68；95%置信区间：0.24 - 1.93，P = 0.47）。此外，与处于最低类别者相比，多不饱和脂肪酸/饱和脂肪酸指数最高的人群PV疾病严重程度高9%。然而，在所有模型中这种关联并不显著（比值比：1.09；95%置信区间：0.34 - 3.51，P = 0.88）。
我们的研究证据表明，多不饱和脂肪酸/饱和脂肪酸比值与ω-6/ω-3指数之间的关系并不显著。然而，需要病例对照研究来证实这些发现。
