核受体共抑制因子
Nuclear receptor corepressors.
作者信息
Lazar Mitchell A
机构信息
Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, The Penn Diabetes Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
出版信息
Nucl Recept Signal. 2003;1:e001. doi: 10.1621/nrs.01001. Epub 2003 Jun 12.
Abstract
The ability of NR LBDs to transfer repression function to a heterologous DNA binding domain, and the cross-squelching of repression by untethered LBDs, has suggested that repression is mediated by interactions with putative cellular corepressor proteins. The yeast-two hybrid screen for protein interactors has proven to be the key to the isolation and characterization of corepressors. This short review will focus on N-CoR and SMRT.
摘要
核受体配体结合结构域（NR LBDs）将抑制功能转移至异源DNA结合结构域的能力，以及非束缚型LBDs对抑制的交叉抑制作用，表明抑制作用是通过与假定的细胞共抑制蛋白相互作用介导的。用于蛋白质相互作用分子的酵母双杂交筛选已被证明是分离和鉴定共抑制因子的关键。这篇简短的综述将聚焦于核受体辅阻遏蛋白（N-CoR）和视黄酸和甲状腺激素受体沉默调节因子（SMRT）。
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