Federspiel A, Müller T J, Horn H, Kiefer C, Strik W K
Department of Psychiatric Neurophysiology, University Hospital of Clinical Psychiatry, Bern, Switzerland.
J Neural Transm (Vienna). 2006 Oct;113(10):1403-15. doi: 10.1007/s00702-006-0434-5. Epub 2006 Apr 11.
Functional magnetic resonance imaging (fMRI) is presently either performed using blood oxygenation level-dependent (BOLD) contrast or using cerebral blood flow (CBF), measured with arterial spin labeling (ASL) technique. The present fMRI study aimed to provide practical hints to favour one method over the other. It involved three different acquisition methods during visual checkerboard stimulation on nine healthy subjects: 1) CBF contrast obtained from ASL, 2) BOLD contrast extracted from ASL and 3) BOLD contrast from Echo planar imaging. Previous findings were replicated; i) no differences between the three measurements were found in the location of the activated region; ii) differences were found in the temporal characteristics of the signals and iii) BOLD has significantly higher sensitivity than ASL perfusion. ASL fMRI was favoured when the investigation demands for perfusion and task related signal changes. BOLD fMRI is more suitable in conjunction with fast event related design.
功能磁共振成像（fMRI）目前要么使用基于血氧水平依赖（BOLD）对比进行，要么使用通过动脉自旋标记（ASL）技术测量的脑血流量（CBF）进行。本fMRI研究旨在提供实用提示，以支持选择一种方法而非另一种方法。该研究在对九名健康受试者进行视觉棋盘格刺激期间涉及三种不同的采集方法：1）从ASL获得的CBF对比；2）从ASL提取的BOLD对比；3）来自回波平面成像的BOLD对比。先前的研究结果得到了重复验证；i）在激活区域的位置未发现三种测量之间存在差异；ii）在信号的时间特征方面发现了差异；iii）BOLD的灵敏度显著高于ASL灌注。当研究需要灌注和与任务相关的信号变化时，ASL fMRI更受青睐。BOLD fMRI更适合与快速事件相关设计相结合。
