Boscolo Galazzo Ilaria, Storti Silvia F, Formaggio Emanuela, Pizzini Francesca B, Fiaschi Antonio, Beltramello Alberto, Bertoldo Alessandra, Manganotti Paolo
Department of Neurological and Movement Sciences, Section of Neurology, University of Verona, Italy.
J Magn Reson Imaging. 2014 Oct;40(4):937-48. doi: 10.1002/jmri.24432. Epub 2013 Nov 4.
To assess the applicability of arterial spin labeling (ASL) in comparison to blood-oxygenation-level-dependent (BOLD) contrast fMRI in detecting brain activations elicited by active and passive hand movements.
A block design for ASL and BOLD fMRI was applied in 8 healthy subjects using active and passive hand tasks. Data analyses were performed at individual and group level, comparing both the different movements and the performance of the two techniques.
Group analyses showed involvement of the same areas during both tasks, as the contralateral sensorimotor cortex, supplementary motor area, cerebellum, inferior parietal lobes, thalamus. ASL detected smaller activation volumes than BOLD, but the areas had a high degree of colocalization. Few significant differences (P < 0.05) were found when the two tasks were compared for the number of activated voxels, coordinates of center of mass, and CBF estimates. Considering together all the areas, the mean %BOLD change was 0.79 ± 0.27 and 0.73 ± 0.24 for the active and passive movements respectively, while the mean %CBF changes were 34.1 ± 8.9 and 27.1 ± 14.8.
Our findings confirm passive and active tasks are strongly coupled, supporting the importance of passive tasks as a diagnostic tool in the clinical setting. ASL fMRI proved suitable for functional mapping and quantifying CBF changes, making it a promising technique for patient cohort applications.
与血氧水平依赖性功能磁共振成像（BOLD）对比，评估动脉自旋标记（ASL）在检测主动和被动手部运动引发的脑激活方面的适用性。
对8名健康受试者应用ASL和BOLD功能磁共振成像的组块设计，采用主动和被动手部任务。在个体和组水平上进行数据分析，比较不同运动以及两种技术的性能。
组分析显示，在两项任务中相同区域均有参与，如对侧感觉运动皮层、辅助运动区、小脑、顶下小叶、丘脑。ASL检测到的激活体积比BOLD小，但区域有高度的共定位。在比较两项任务的激活体素数量、质心坐标和脑血流量（CBF）估计值时，发现很少有显著差异（P < 0.05）。综合所有区域，主动运动和被动运动的平均%BOLD变化分别为0.79 ± 0.27和0.73 ± 0.24，而平均%CBF变化分别为34.1 ± 8.9和27.1 ± 14.8。
我们的研究结果证实主动和被动任务紧密相关，支持被动任务作为临床诊断工具的重要性。ASL功能磁共振成像被证明适用于功能图谱绘制和量化CBF变化，使其成为患者队列应用中有前景的技术。
