de Francesco Daher Elizabeth, de Sousa Barros Fernando Antonio, da Silva Júnior Geraldo Bezerra, Takeda Christianne Fernandes Valente, Mota Rosa Maria Salani, Ferreira Marúsia Thomaz, Martins Julieta Cunha, Oliveira Soraya Alves Jacinto, Gutiérrez-Adrianzén Oswaldo Augusto
Department of Internal Medicine, Faculdade de Medicina, Hospital Universitário Walter Cantídio.
Am J Trop Med Hyg. 2006 Apr;74(4):600-3.
We performed a retrospective study of 164 human immunodeficiency virus (HIV)-infected patients with disseminated histoplasmosis to identify the risk factors for death. Death occurred in 32% of the cases. Univariate analysis identified the following risk factors: diarrhea (odds ratio [OR] = 3.9, P = 0.001), neurologic manifestations (OR = 5.8, ; P = 0.001), hemoglobin level < 8.0g/dL (OR = 2.7, P = 0.004), urea level 2 times the normal upper limit (OR = 5.0, P < 0.001), creatinine level > 1.5 mg/dL (OR = 2.9, P = 0.005), aspartate aminotransferase (AST) level > 2.5 times the normal upper limit (OR = 3.1, P = 0.01), respiratory insufficiency (OR = 9.7, P < 0.001), sepsis (OR = 20.2, P < 0.001), and acute renal failure (OR = 2.5, P = 0.011). A hemoglobin level < 8.0 g/dL (OR = 3.8, P = 0.008), an AST level >or= 2.5 times the normal limit (OR = 1.0, P = 0.007), acute renal failure (OR = 2.96, P = 0.015), and respiratory insufficiency (OR = 12.2, P = 0.01) were independent risk factors for death.
我们对164例播散性组织胞浆菌病的人类免疫缺陷病毒（HIV）感染患者进行了一项回顾性研究，以确定死亡的危险因素。32%的病例发生了死亡。单因素分析确定了以下危险因素：腹泻（比值比[OR]=3.9，P=0.001）、神经系统表现（OR=5.8，P=0.001）、血红蛋白水平<8.0g/dL（OR=2.7，P=0.004）、尿素水平为正常上限的2倍（OR=5.0，P<0.001）、肌酐水平>1.5mg/dL（OR=2.9，P=0.005）、天冬氨酸转氨酶（AST）水平>正常上限的2.5倍（OR=3.1，P=0.01）、呼吸功能不全（OR=9.7，P<0.001）、脓毒症（OR=20.2，P<0.001）和急性肾衰竭（OR=2.5，P=0.011）。血红蛋白水平<8.0g/dL（OR=3.8，P=0.008）、AST水平≥正常上限的2.5倍（OR=1.0，P=0.007）、急性肾衰竭（OR=2.96，P=0.015）和呼吸功能不全（OR=12.2，P=0.01）是死亡的独立危险因素。
