谷胱甘肽在二硫键形成及内质网产生的氧化应激中的作用
The role of glutathione in disulphide bond formation and endoplasmic-reticulum-generated oxidative stress.
作者信息
Chakravarthi Seema, Jessop Catherine E, Bulleid Neil J
机构信息
The Faculty of Life Sciences, University of Manchester, The Michael Smith Building, Oxford Road, Manchester M13 9PT, UK.
出版信息
EMBO Rep. 2006 Mar;7(3):271-5. doi: 10.1038/sj.embor.7400645.
Abstract
Glutathione is a ubiquitous molecule found in all parts of the cell where it fulfils a range of functions from detoxification to protection from oxidative damage. It provides the main redox buffer for cells and as such has been implicated in the formation of native disulphide bonds. However, the discovery of the enzyme Ero1 has called into question the exact role of glutathione in this process. In this review, we discuss the arguments for and against a role for glutathione in facilitating disulphide-bond formation and consider its role in protecting the cell from endoplasmic-reticulum-generated oxidative stress.
摘要
谷胱甘肽是一种普遍存在的分子，存在于细胞的各个部位，在细胞中发挥着从解毒到防止氧化损伤等一系列功能。它为细胞提供主要的氧化还原缓冲，因此与天然二硫键的形成有关。然而，Ero1酶的发现对谷胱甘肽在此过程中的具体作用提出了质疑。在这篇综述中，我们讨论了支持和反对谷胱甘肽在促进二硫键形成中发挥作用的观点，并考虑了其在保护细胞免受内质网产生的氧化应激方面的作用。
相似文献
1
The role of glutathione in disulphide bond formation and endoplasmic-reticulum-generated oxidative stress.谷胱甘肽在二硫键形成及内质网产生的氧化应激中的作用
EMBO Rep. 2006 Mar;7(3):271-5. doi: 10.1038/sj.embor.7400645.
2
Balanced Ero1 activation and inactivation establishes ER redox homeostasis.平衡 Ero1 的激活和失活可建立内质网的氧化还原平衡。
J Cell Biol. 2012 Mar 19;196(6):713-25. doi: 10.1083/jcb.201110090. Epub 2012 Mar 12.
3
Endoplasmic Reticulum Transport of Glutathione by Sec61 Is Regulated by Ero1 and Bip.Sec61介导的谷胱甘肽在内质网中的转运受Ero1和Bip调控。
Mol Cell. 2017 Sep 21;67(6):962-973.e5. doi: 10.1016/j.molcel.2017.08.012. Epub 2017 Sep 14.
4
Competition between glutathione and protein thiols for disulphide-bond formation.谷胱甘肽与蛋白质硫醇在二硫键形成上的竞争。
Nat Cell Biol. 1999 Jul;1(3):130-5. doi: 10.1038/11047.
5
A flavoprotein oxidase defines a new endoplasmic reticulum pathway for biosynthetic disulphide bond formation.一种黄素蛋白氧化酶为生物合成二硫键形成定义了一条新的内质网途径。
Nat Cell Biol. 2001 Oct;3(10):874-82. doi: 10.1038/ncb1001-874.
6
Ero1 and redox homeostasis in the endoplasmic reticulum.内质网中的Ero1与氧化还原稳态
Biochim Biophys Acta. 2008 Apr;1783(4):549-56. doi: 10.1016/j.bbamcr.2007.12.011. Epub 2007 Dec 23.
7
Modulation of cellular disulfide-bond formation and the ER redox environment by feedback regulation of Ero1.通过Ero1的反馈调节对细胞二硫键形成和内质网氧化还原环境的调控
Cell. 2007 Apr 20;129(2):333-44. doi: 10.1016/j.cell.2007.02.039.
8
Two pairs of conserved cysteines are required for the oxidative activity of Ero1p in protein disulfide bond formation in the endoplasmic reticulum.在内质网中蛋白质二硫键形成过程中，Ero1p的氧化活性需要两对保守的半胱氨酸。
Mol Biol Cell. 2000 Sep;11(9):2833-43. doi: 10.1091/mbc.11.9.2833.
9
Multiple ways to make disulfides.多种形成二硫键的方法。
Trends Biochem Sci. 2011 Sep;36(9):485-92. doi: 10.1016/j.tibs.2011.05.004. Epub 2011 Jul 19.
10
Oxidative protein folding: from thiol-disulfide exchange reactions to the redox poise of the endoplasmic reticulum.氧化蛋白折叠：从硫醇-二硫键交换反应到内质网的氧化还原平衡
Free Radic Biol Med. 2015 Mar;80:171-82. doi: 10.1016/j.freeradbiomed.2014.07.037. Epub 2014 Aug 1.
引用本文的文献
1
Mode of Action of Toxin 6-Hydroxydopamine in SH-SY5Y Using NMR Metabolomics.利用核磁共振代谢组学研究毒素6-羟基多巴胺在SH-SY5Y细胞中的作用模式
Molecules. 2025 Aug 12;30(16):3352. doi: 10.3390/molecules30163352.
2
Cracking the Code of Oocyte Quality: The Oxidative Stress Link to IVF Success.破解卵母细胞质量密码：氧化应激与体外受精成功的关联
Int J Mol Sci. 2025 Jul 2;26(13):6377. doi: 10.3390/ijms26136377.
3
Nanomedicine-Driven Modulation of Reductive Stress for Cancer Therapy.纳米医学驱动的还原应激调节用于癌症治疗
Adv Sci (Weinh). 2025 Aug;12(32):e01968. doi: 10.1002/advs.202501968. Epub 2025 Jun 26.
4
Increased production of riboflavin in Ashbya gossypii by endoplasmic reticulum stresses.通过内质网应激提高棉阿舒囊霉中核黄素的产量。
Arch Microbiol. 2025 Jun 5;207(7):167. doi: 10.1007/s00203-025-04359-3.
5
Synthesis and Evaluation of Trehalose-Based Mertansine Warheads for Bacillus Calmette-Guérin Delivery of Anticancer Agents.用于卡介苗递送抗癌药物的基于海藻糖的美登素弹头的合成与评价
Chembiochem. 2025 Sep 12;26(16):e202500390. doi: 10.1002/cbic.202500390. Epub 2025 Jul 9.
6
Ultra-Fine 3D Bioprinting of Dynamic Hyaluronic Acid Hydrogel for in Vitro Modeling.用于体外建模的动态透明质酸水凝胶的超精细3D生物打印
Adv Mater. 2025 Jul;37(30):e2500315. doi: 10.1002/adma.202500315. Epub 2025 May 13.
7
Identification and Characterization of Oxidative Stress and Endoplasmic Reticulum Stress-Related Genes in Esophageal Cancer.食管癌中氧化应激与内质网应激相关基因的鉴定与特征分析
J Cancer. 2025 Mar 21;16(7):2103-2123. doi: 10.7150/jca.104376. eCollection 2025.
8
Active control of mitochondrial network morphology by metabolism-driven redox state.通过代谢驱动的氧化还原状态对线粒体网络形态进行主动控制。
Proc Natl Acad Sci U S A. 2025 Apr 22;122(16):e2421953122. doi: 10.1073/pnas.2421953122. Epub 2025 Apr 17.
9
Dissecting Causal Relationships Between Immune Cells, Plasma Metabolites, and PCOS: Evidence From Mediating Mendelian Randomization Analysis.剖析免疫细胞、血浆代谢物与多囊卵巢综合征之间的因果关系：来自中介孟德尔随机化分析的证据
Int J Womens Health. 2025 Mar 17;17:807-823. doi: 10.2147/IJWH.S508352. eCollection 2025.
10
Integrative single-cell metabolomics and phenotypic profiling reveals metabolic heterogeneity of cellular oxidation and senescence.整合单细胞代谢组学和表型分析揭示细胞氧化和衰老的代谢异质性。
Nat Commun. 2025 Mar 20;16(1):2740. doi: 10.1038/s41467-025-57992-3.
本文引用的文献
1
Generating disulfides enzymatically: reaction products and electron acceptors of the endoplasmic reticulum thiol oxidase Ero1p.酶促生成二硫键：内质网硫醇氧化酶Ero1p的反应产物和电子受体。
Proc Natl Acad Sci U S A. 2006 Jan 10;103(2):299-304. doi: 10.1073/pnas.0506448103. Epub 2006 Jan 3.
2
On the mechanism of sensing unfolded protein in the endoplasmic reticulum.内质网中未折叠蛋白的感知机制
Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):18773-84. doi: 10.1073/pnas.0509487102. Epub 2005 Dec 19.
3
A bacterial glutathione transporter (Escherichia coli CydDC) exports reductant to the periplasm.一种细菌谷胱甘肽转运蛋白（大肠杆菌CydDC）将还原剂输出到周质中。
J Biol Chem. 2005 Sep 16;280(37):32254-61. doi: 10.1074/jbc.M503075200. Epub 2005 Jul 22.
4
The human protein disulphide isomerase family: substrate interactions and functional properties.人类蛋白质二硫键异构酶家族：底物相互作用及功能特性
EMBO Rep. 2005 Jan;6(1):28-32. doi: 10.1038/sj.embor.7400311.
5
Glutathione directly reduces an oxidoreductase in the endoplasmic reticulum of mammalian cells.谷胱甘肽直接还原哺乳动物细胞内质网中的一种氧化还原酶。
J Biol Chem. 2004 Dec 31;279(53):55341-7. doi: 10.1074/jbc.M411409200. Epub 2004 Oct 26.
6
Degradation of misfolded proteins prevents ER-derived oxidative stress and cell death.错误折叠蛋白质的降解可防止内质网衍生的氧化应激和细胞死亡。
Mol Cell. 2004 Sep 10;15(5):767-76. doi: 10.1016/j.molcel.2004.08.025.
7
Glutathione is required to regulate the formation of native disulfide bonds within proteins entering the secretory pathway.谷胱甘肽是调节进入分泌途径的蛋白质中天然二硫键形成所必需的。
J Biol Chem. 2004 Sep 17;279(38):39872-9. doi: 10.1074/jbc.M406912200. Epub 2004 Jul 14.
8
Structure of Ero1p, source of disulfide bonds for oxidative protein folding in the cell.Ero1p的结构，细胞中氧化蛋白质折叠的二硫键来源。
Cell. 2004 May 28;117(5):601-10. doi: 10.1016/s0092-8674(04)00418-0.
9
Glutathione limits Ero1-dependent oxidation in the endoplasmic reticulum.谷胱甘肽可限制内质网中依赖Ero1的氧化作用。
J Biol Chem. 2004 Jul 30;279(31):32667-73. doi: 10.1074/jbc.M404992200. Epub 2004 May 25.
10
Signaling the unfolded protein response from the endoplasmic reticulum.来自内质网的未折叠蛋白反应信号传导。
J Biol Chem. 2004 Jun 18;279(25):25935-8. doi: 10.1074/jbc.R400008200. Epub 2004 Apr 7.
Zotero 插件