Chakravarthi Seema, Jessop Catherine E, Bulleid Neil J
The Faculty of Life Sciences, University of Manchester, The Michael Smith Building, Oxford Road, Manchester M13 9PT, UK.
EMBO Rep. 2006 Mar;7(3):271-5. doi: 10.1038/sj.embor.7400645.
Glutathione is a ubiquitous molecule found in all parts of the cell where it fulfils a range of functions from detoxification to protection from oxidative damage. It provides the main redox buffer for cells and as such has been implicated in the formation of native disulphide bonds. However, the discovery of the enzyme Ero1 has called into question the exact role of glutathione in this process. In this review, we discuss the arguments for and against a role for glutathione in facilitating disulphide-bond formation and consider its role in protecting the cell from endoplasmic-reticulum-generated oxidative stress.
谷胱甘肽是一种普遍存在的分子，存在于细胞的各个部位，在细胞中发挥着从解毒到防止氧化损伤等一系列功能。它为细胞提供主要的氧化还原缓冲，因此与天然二硫键的形成有关。然而，Ero1酶的发现对谷胱甘肽在此过程中的具体作用提出了质疑。在这篇综述中，我们讨论了支持和反对谷胱甘肽在促进二硫键形成中发挥作用的观点，并考虑了其在保护细胞免受内质网产生的氧化应激方面的作用。
