采用核磁共振技术测定乌苏烷型三萜类化合物的结构

Structure determination of ursene-type triterpenes by NMR techniques.

作者信息

Ahmed Zaheer, Ali Dildar, Malik Abdul

机构信息

International Center for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, 75270-Karachi, Pakistan.

出版信息

Magn Reson Chem. 2006 Jul;44(7):717-9. doi: 10.1002/mrc.1803.

DOI:10.1002/mrc.1803

PMID:16607673

Abstract

Two new ursene-type triterpenes, nudicauline A and nudicauline B, have been isolated from Launaea nudicaulis. Their structures have been assigned as 3beta-hydroxy-urs-11-ene (1) and 3beta-acetyl-urs-11-ene (2), respectively, by extensive NMR studies. In addition, olean-11,13(18)-diene (3), 3beta-hydroxy-13(28)-epoxy-urs-11-ene (4) and 3-keto-13(28)-epoxy-urs-11-ene (5) are also reported for the first time from this species.

摘要

从裸茎栓果菊中分离出了两种新的乌苏烷型三萜化合物，裸茎素A和裸茎素B。通过广泛的核磁共振研究，它们的结构分别被确定为3β-羟基-乌苏-11-烯（1）和3β-乙酰基-乌苏-11-烯（2）。此外，该物种还首次报道了齐墩果-11,13(18)-二烯（3）、3β-羟基-13(28)-环氧-乌苏-11-烯（4）和3-酮-13(28)-环氧-乌苏-11-烯（5）。