[用于药物分析的膜选择性电极。注释II]
[Membrane-selective electrodes for drug analysis. Note II].
作者信息
Bibire Nela, Dorneanu V
机构信息
Universitatea de Medicină gi Farmacie Gr.T. Popa Iaşi, Facultatea de Farmacie, Disciplina de Chimie Analitică.
出版信息
Rev Med Chir Soc Med Nat Iasi. 2005 Apr-Jun;109(2):426-30.
Seven membrane-selective electrodes with PVC matrix and liquid-membrane for N-butylscopolamine with different electroactive materials are presented. These electrodes have a linear response in the concentration range of 10(-6) - 10(-2) M N-butylscopolamine bromide, with a detection limit between 4.58 x 10(-7)M and 1.09 x 10(-6)M. These electrodes were used with good results for quantitative assay by direct potentiometry and potentiometric titration of N-butylscopolamine bromide from pharmaceutical formulations. Recovery was between 95.50% and 99.20% for N-butylscopolamine bromide of injectable solutions.
介绍了七种带有PVC基质和液膜的膜选择性电极，用于检测含有不同电活性材料的N-丁基东莨菪碱。这些电极在10(-6)-10(-2)M溴化N-丁基东莨菪碱的浓度范围内具有线性响应，检测限在4.58×10(-7)M至1.09×10(-6)M之间。这些电极用于药物制剂中溴化N-丁基东莨菪碱的直接电位法和电位滴定法定量分析，效果良好。注射用溶液中溴化N-丁基东莨菪碱的回收率在95.50%至99.20%之间。
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